CV: Daniel Choo MD

Daniel Choo, MD
Associate Professor and Director, Division of Otology/Neurotology
Department of Otolaryngology
College of Medicine
University of Cincinnati

Answers questions in the following forums:

Ear, Nose, and Throat Disorders

Practice Address:

Medical Arts Building
222 Piedmont Ave. #5200
Cincinnati, OH 45219

Children's Hospital Medical Center
Dept. of Pediatric Otolaryngology
Cincinnati, OH 45229

Education:

MD State University of New York
BA University of Pennsylvania

Post Graduate Training:

1989-1990 Surgical Internship, State University of New York
1990-1994 Resident in Otolaryngology, State University of New York
1994-1995 Fellowship, Clinical and Surgical Neuro-Otology Training, Ear Research Foundation, Sarasota, FL
1995-1996 IRTA Fellowship, Laboratory of Cellular Biology, NIDCD, Rockville, MD
1996-1998 Fellowship, Laboratory of Cellular Biology, NIDCD, Neuro-Otology Branch, NIDCD
1989-1999 Senior Staff Scientist, Neuro-Otology Branch, NIDCD

Licensure or Certification:

Certification: American Board of Otolaryngology
Diplomate: National Board of Medical Examiners

Associations:

Fellow American Academy of Otolaryngology - Head and Neck Surgery
American Medical Association
AME Board of Medical Specialists
Association for Research in Otolaryngology
American College of Surgeons
American Auditory Society
Society of University Otolaryngologists-Head and Neck Surgeons
The American Society of Pediatric Otolaryngology
Society for Ear, Nose & Throat Advances In Children

Partial List of Publications:

Zur KB, Holland SK, Yuan W, Choo DI. “Functional magnetic resonance imaging: contemporary and future use. Curr Opin Otolaryngol Head Neck Surg. 2004 Oct; 12(5):374-377.
Dou, Hongwei, Greinwald, J., Choo, D., “Coexpressions of Pendrin, Vaculor H+-ATPase a4 subunit and Carbonic Anhydrase II in Epitheal Cells of Murine Endolymphatic Sac”, Journal of Histochemistry and Cytochemistry, 2004 Oct;52(10):1377-84..
Li R, Greinwald JH, Yang L, Choo DI, Wenstrup RJ, Guan MX. Molecular analysis of mitochondrial 12S rRNA and tRNASer(UCN) genes in pediatric subjects with nonsyndromic hearing loss JMedGenet. Aug.;41 (8): 615-620, 2004.
Lonser R., Kim HJ., Butman J., Vortmeyer A., Choo D., Oldfield E., “ Tumors of the Endolymphatic Sac in von Hippel-Lindau Disease”, NEngl J Med, Jun 10;350;(24)2481-6, 2004.
Pilipenko V, Reese A, Choo, DI, Greinwald JH. Genomic organization and expression analysis of the murine Fam3c gene. Gene 2004 Jun 23;335:159- 168 2004.
Guo, Y., Pilipenko, V., Lim, L., Dou, H., Johnson, L., Choo, D., et. al., “Refining the DFNB17 Interval in Consanguineous Indian Families”, Mol Biol Rep, June 31: 97-105, 2004.
Choo D, Shotland L, Mastroianni M, Glenn G, van Waes C, Linehan Wm, Oldfield EH, Enodolymphatic sac tumors in von Hippel-Lindau disease, J Neurosur. 2004 Jun 10;350(24):2481-6.
Li R., Greinwald JH, Yang L, Choo, DI, Wenstrup R, Guan M-X.,”Molecular analysis of the mitochondrial 12SrRNA and tRNA ser(ucn) genes in paediatric subjects with non-syndromic hearing loss. JMG 2004 April 16:54-24.
Chadwell JB, Halsted MJ, Choo DI, Greinwald JH, Benton C., “The Cochlear Cleft”, AJNR-Am J Neuroradio. 2004 Jan; 25(1):21-24.
Shotland, L., Mastrioanni, MA., Choo, D., Szymko-Bennett, Y., Dally, LG., et.al., “Audiologic Manifestations of Patients with Post-Treatment Lyme Disease Syndrome”, Ear and Hearing, December 2003, 24(6):508-517.
Shotland, L., Mastrioanni, MA., Choo, D., Szymko-Bennett, Y., Dally, LG., et.al., “Audiologic Manifestations of Patients with Post-Treatment Lyme Disease Syndrome”, Ear and Hearing, December 2003, 24(6):508-517.
Madden, C., Halsted, M., Hopkin, R., Choo, D., et. al., “Temporal Bone Abnormalities Associated with Hearing Loss in Waardenburg Syndrome”, The Laryngoscope, 113:2035-2041, Nov. 2003.
Lim, L., Bradshaw, JK., Guo, Y., Pilipenko, V., Madden, C., Choo, D., et. al., “Genetic heterogeneity in the Midwestern US hearing loss population”, Arch of Otol-HNS, Aug. 2003, 129(8)836-840.
D. Choo, “Mice Lacking the B1 Subunit of H+ -ATPase Have Normal Hearing”, Hear Res, 180(2003)76-84.
D. Choo, “ Enlarged vestibular aqueduct syndrome in the pediatric population” Otology & Neurotology, 2003 July; 24(4):625-32.
Merves,M., C.M. Krane, D. Choo, “Expression of Aquaporin 1 and 5 in the Developing Mouse Inner Ear and Audiovestibular Assessment of Aqp5 Null Mutant.”, J Assoc Res Otolaryngoly 2003 Jun;4(2):264-75.
D. Choo, M. Merves, C. Krane, H. Dou, J. Greinwald, A. Menon, Expression of Aquaporin 1 and 5 in the Developing Mouse Inner Ear and Audiovestibular Assessment of an Aqp5 Null Mutant” J Assoc Res Otolaryngol. 2003 Jun;4(2):264-75.
Dou, H, Finberg, K., Cardell, E.L., Lifton, R., D. Choo, “Mice lacking the B1 subunit of H(+)-ATPase have normal hearing.” Hearing Research, 180(1-2):76-84, 2003
D. Choo, “Treatment of Chronic Supprative otitis media has changed”, Infectious Diseases in Children Volume 15, pg 52. November 11, 2002.
D. Choo, D. Steward, M. Pensak. Meningioma Involving Meckel's Cave: Transpetrosal Surgical Anatomy and Clinical Considerations. Ann Otol Rhinol Laryngol. 2002 Sep;111(9):850-4.
Madden C, Rutter MJ, Hilbert L, Greinwald J, Choo D: “Pediatric Cochlear Implantation in Auditory Neuropathy” Arch Oto-HNS 2002; 128 (9): 1026-1030.
D. Choo, “Current and emerging management strategies in chronic ear disease: proceedings of a clinical symposium” ENT journal, supplement; August 2002. Vol 81. No 8.
D. Choo, Madden, C., Hilbert, L., Greinwald, J., Rutter, M.: “Pediatric cochlear implantation in auditory neuropathy” Otol Neurotol. 2002 Mar;23(2):163-8.
D. Choo, “The impact of molecular genetics on the clinical management of pediatric sensorineural hearing loss.”, JPediatr, 140(2):148-9, 2002
D. Choo, D. Witiak: “Cochlear Implantation” Current Opinion in Otolaryngology and Head and Neck Surgery, 2001 October 9(5):299-304.
M. Merves, B. Bobbitt, K. Parker, D. Choo. Developmental Expression of Aquaporin 2 in the Mouse Inner Ear. Laryngoscope. 2000 Nov;110(11):1925-30.
D. Steward, D. Choo, M. Pensak: “Selective Indications for the Management of Extensive Anterior Epitympanic Cholesteatoma Via Combined Transmastoid/Middle Fossa Approach.” The Laryngoscope, 2000 Oct;110(10 Pt 1):1660-6.
14. J. Liu, M.J. Rutter, D.I. Choo, J.P. Willging: “Congenital Cholesteatoma of the Middle Ear.” Clinical Pediatrics, 2000 Sep;39(9):549-51.
D Chen, J House, A Lalwani, D Choo. Aspergillus Mastoiditis in Acquired Immunodeficiency Syndrome. Amer J Otology 1999 Sep;20(5):561-7.
H. Morsli, F. Tuorto, D. Choo, M. Postiglione, A. Simeone, D. Wu. Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. Development, June, 1999, Vol. 126, pp 2335-43.
D Acampora, V Avantaggiato, F Tuorto, P Barone, M Perera, D Choo, D Wu, G Corte, A Simeone. Differential Transcriptional Control as the Major Molecular Event in Generating Otxl-/- and Otx2-/- Divergent Phenotypes. Development, 1999, Vol. 126, pp 1417-26.
D. Choo, J-L Sanne, D. Wu: “The Differential Sensitivities of Inner Ear Structures to Retinoic Acid during Development” Developmental Biology 1998 Dec 1;204(1):136-50.
H Morsli, D Choo, Allen Ryan, Randy Johnson, DK Wu. Development of the Mouse Inner Ear and its Sensory Organs. J Neuroscience, 1998, Vol. 18:9, pp 3327-35.
D Choo, JL Sanne, DK Wu. The Differential Sensitivity of Inner Ear Structures to Retinoic Acid during Development. Developmental Biology, 1998, Vol. 204, pp 136-50.
DK Wu, F Nunes, D Choo. Axial Specification for Sensory Organs Versus Non-Sensory Structures of the Chicken Inner Ear. Development, l998, Vol.125, pp 11-20.

Research:

Endolymphatic sac tumors in a population of patients with von Hippel Lindau Disease. Natural history, pathobiology, and a prospective, non-randomized trial of hearing preservation surgery in patients with early stage tumors.
A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients with Suspected Chronic Lyme Infection and Selected Control Populations.
A Phase 1 study to evaluate the safety and immunogenicity of a nontypable Hemophilus influenze vaccine for otitis media.
A randomized placebo-controlled trial Alendronate in the treatment of Polyostotic Fibrous Dysplasia and the McCune Albright Syndrome.
Screening and natural history of patients with polyostotic fibrous dysplasia and the McCune Albright Syndrome.
Patterns of Cortical Activation in Pediatric Cochlear Implant Candidates (00-9-23) CHMC
Molecular Analysis of the Pathophysiology and Vaccine-Mediated Prevention of Cytomegalovirus-Induced Sensorineural Deafness in a Guinea Pig Model of Congenital Infection.
FMRI for Selection of Children for Cochlear Implantation
R01 application focusing on Mitochondrial DNA Mutations relating to deafness and Aminoglycoside-induced hearing loss.
R01 Independent application entitled Behavioral & Genetic Tools in Early Onset Hearing Loss is complete.

Hospital Appointments:

1994-1995 Clinical Instructor, Dept. of Otolaryngology/Neuro-Otology, University of Pennsylvania
1995-1996 IRTA Fellow, Laboratory of Cellular Biology, NIDCD
1996-1998 Senior Staff Fellow, Laboratory of Cellular Biology, NIDCD
1998-2004 Assistant Professor, Dept. of Otolaryngology - Head and Neck Surgery, Division of Otology/Neurotology, Children's Hospital Medical Center
2004-present Associate Professor Children’s Hospital Medical Center/ University of Cincinnati

Partial List of Presentations:

Annual Meeting of the Prospere Meniere Society (1996). The developmental effects of RA on morphogenesis of the endolymphatic sac of the chick inner ear; implications for Meniere's Disease.
Severance Medical College Inaugurative Symposium, Department of Otolaryngology. Seoul, Korea (1997). Clinical and Molecular Studies of Endolymphatic Sac tumors in von Hippel Lindau Disease.
National VHL Alliance, Annual Conference. Bethesda, Maryland (1997). Advances in the diagnosis and management of endolymphatic sac tumors in von Hippel Lindau Disease
National VHL Alliance, Annual Conference. Seattle, Washington (1998). Clinical and research studies of hearing and balance disorders due to endolymphatic sac tumors in VHL disease.
Endolymphatic Sac Tumors - Sixth International Patient/Provider Conference - Atlanta, Georgia, June 5, 1999.
(1998) - Endolymphatic Sac Tumors: Clinical and Molecular Genetic Studies. Am. Academy of Otolaryngology - Head and Neck Surgery, Annual Meeting, Scientific Forum, San Antonio, Texas.
(1998) - Abnormal development of the inner ears of mice lacking OTX genes. Molecular Biology of Hearing and Deafness, Bethesda, Maryland.
(1/00) - Proteus Syndrome: A Case Report. Middle Section at the Triologic Meeting in Cincinnati, OH.
Triologic Meeting - Cincinnati, Ohio - January 21-23, 2000 (1) "The Importance of Molecular Genetics for the Otologist" (2) "Meningioma Involving Meckel's Cave: Transpectrosal Surgical Anatomy and Clinical Considerations" (3) "Molecular Mechanisms of Fluid Homeostasis in the Developing Mouse Inner Ear" (4) "Otolaryngologic Manifestations & Mgmt of Proteus Syndrome"
COSM (American Otological Society, Inc.) Palm Desert, California, May 11, 2001 Molecular Patterning of Endolymphatic duct/sac.
American Otological Society, Inc. Palm Desert, California, May 11, 2001. Cochlear Implantation in Auditory Neuropathy.
15TH National Acoustic Neuroma Association Symposium- June 23, 2001. “Gene Defects in NF2”
Association for Research in Otolaryngology 2001, Midwinter meeting. St. Petersburg Beach, Florida. “Gene Expression Patterns in the Developing Mouse Endolymphatic Duct and Sac.’
Association for Research in Otolaryngology 2001, Midwinter meeting. St. Petersburg Beach, Florida. “Expression of Aquaporins 1 and 5 in the Developing Mouse Inner Ear.”
Eastern Kentucky Neonatal Nurse Association, Fall Meeting, 9/02 Mt. Olivet, Kentucky, “Congenital Hearing Loss”
Cincinnati Children’s Hospital Medical Center, The Regional Infant Hearing Program, Hearing Loss from A-Z in Infants and Toddlers. September, 2002. “Pediatric Cochlear Implantation”.
American Academy of Otolaryngology, Fall Meeting, San Diego, California- September, 2002 “Medical and Surgical Management of Chronic Suppurative Otitis”
American Academy of Otolaryngology, Fall Meeting, San Diego, California- September, 2002 “ New Horizons in Pediatric Hearing Loss”
Ohio School Speech and Language and Audiologic Convention at Kingsgate Marriott. “Pediatric Sensorineural Hearing loss”, October 2003. Ampithertre II.
Ohio University College of Osteopathic Medicine (CORE) System, Otorhinolaryngology-Head and Neck Surgery Residency Program Advisory Committee Education Day Program. Columbus, Ohio. “Diagnostic workup and management of pediatric sensorineural hearing loss”. November 13, 2003
Combined Otolaryngology Spring Meeting in Phoenix, Arizona, April 2004, “Pediatric Hearing Impairment- The Caregiver’s Experience”.
Interdisciplinary Osseointegration Summit-A Colloquium on Osseointegration Biotechnology in Rehabilitation of the Head and Neck, Discuss formation of a study group that would focus on issues related to craniofacial osseointegration. February 2004. Vail, Colorado
Ohio Speech-Language-hearing Association 58th Annual Convention, “Advances in the Management of Pediatric Sensorineural Hearing loss” March 11-13, 2004.Columbus, Ohio
Ohio Speech-Language-hearing Association 58th Annual Convention, Enlarged Vestibular Aqueduct Syndrome” March 11-13, 2004-Columbus, Ohio
Ohio Speech-Language-hearing Association 58th Annual Convention, “UNHS and Advocacy” March 11-13, 2004-Columbus, Ohio
Cincinnati Children’s Hospital Medical Center outpatient department conference, “Current Diagnostic and Therapeutic Options in Pediatric Hearing Loss,” March 19, 2004.
Combined Otolaryngology Spring Meeting-Phoenix, Arizona. “Audiometric, Clinical and Educational Findings in a Pediatric Symptomatic Congenital Cytomegalovirus.” May 3, 2004
Vlll International Cochlear Implant Conference –Indianapolis, Indiana. “Cochlear Implants- May 2004
Vlll International Cochlear Implant Conference –Indianapolis, Indiana. “The Caregiver Experience”- May 2004.
AAO-HNSF Annual Meeting –New York, New York. “Pediatric Sensorineural Hearing Loss: What to Do?”- September 2004.
8th Annual Midwest Neonatology Critical Care Symposium in Covington, Kentucky, “The Diagnosis of Newborn Hearing Loss: A Changing Paradigm”- November 6, 2004

Awards:

1988 - AOA, Medical Student Research Award
1989 - American Academy of Otolaryngology - Medical Student Research Award
1995 - Ear Research Foundation - Fellow-s Award for Excellence
1998 - National Institute of Health - Clinical Center - Director's Award
2001 NIH NIDCD K08-DC00193
2001 Children’s Hospital Medical Center Trustees Award
2002 American College of Surgeons
2003 Research forum moderator for Otology and Neurotology ARO/AAO-HNSF
2003 “Best Doctor’s of the Year Award”