CV: John H Greinwald, Jr MD, FAAP

John H Greinwald, Jr, MD, FAAP
Associate Professor of Otolaryngology and Pediatrics
Director of the Auditory Genetics Laboratory
College of Medicine
University of Cincinnati

Answers questions in the following forums:

Ear, Nose, and Throat Disorders

Practice Address:

Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati, OH 45229

Education:

1987 – M.D. Medical Univ of South Carolina
1983 - B.S. Wofford College

Post Graduate Training:

1987-1988 - Surgical Intern Naval Hospital, Portsmouth
1988-1989 - Student, Flight Surgeon Naval Aeromedical Institute
1991-1995 - Otolaryngology Resident Naval Medical Center, Portsmouth
1996-1998 - Pediatric Otolaryngology, University of Iowa, Fellow

Licensure or Certification:

Certification, American Board of Otolaryngology

Associations:

American Academy of Otolaryngology - Head and Neck Surgery
American Academy of Otolaryngic Allergy
Military Society of Otolaryngologists
American Society of Pediatric Otolaryngologists
Association for Research in Otolaryngology
American Society of Human Genetics
American Academy of Pediatrics

Partial List of Publications:

Hart K, Greinwald JH, Shaffrey CI, Postma GS. "Chyle Leak during Anterior Approach to the Cervical Disk: A rare Neurosurgical Complication." Journal of Neurosurgery; 88:151-154, 1998.
Greinwald JH, Simko EJ. "The diagnosis and management of middle ear osteomas." Ears Nose and Throat Journal; 77(2):134-139, 1998.
Chen AH, Mueller RF, Prasad SD, Greinwald JH, Manaligod J, Muilenburg AC, Verhoeven K, Van Camp G, Smith RJH. “Presymptomatic diagnosis of non-syndromic hearing loss by genotyping.” Archives of Otolaryngology-Head and Neck Surgery; 124:20-24, 1998
Greinwald JH, Wayne S, Chen AH, Scott DA, Zbar RIS, Kraft ML, Prasad S, Ramesh A, Coucke P, Srisailapathy S, Lovett M, Van Camp G, Smith RJH. “Localization of a novel gene for non-syndromic hearing loss, DFNB17, to chromosome region 7q31.” American Journal of Medical Genetics;78:107-113, 1998.
Scott DA, Greinwald JH, Marietta J, Drury S, Swiderski RE, Vinas A, DeAngelis MM, Carmi R, Ramesh A, Kraft ML, Elbedour K, Skvorak AB, Friedman RA, Srisailapathy CRS, Verhoeven K, Van Camp G, Lovett M, Deininger PL, Batzer MA, Morton CC, Keats BJ, Smith RJH, Sheffield VC. "Identification and mutation analysis of a cochlear expressed zinc-finger protein gene at the DFNB7/11 and dn hearing-loss-loci on human chromosome 9q. and mouse chromosome 19". Gene; 215:461-469, 1998.
Greinwald JH, Burke DK, Bonthius DJ, Bauman NM, Smith RJH. "An update of the Iowa experience for the treatment of life-threatening hemangiomas with interferon alpha-2a". Archives of Otolaryngology-Head and Neck Surgery; 125:21-27, 1999.
Lim AT, Wall MP, Greinwald JH. "The effect of dimethylthiourea, melatonin, and hyperbaric oxygen therapy on the survival of reimplanted rabbit auricular composite grafts." Otolaryngology Head and Neck Surgery; 121:231-237, 1999.
Greinwald JH, Burke D, Sato Y, Poust RI, Kimura K, Bauman NM, Smith RJH. "The treatment of lymphangiomas in children: An update of Picibanil (OK-432) sclerotherapy". Otolaryngology Head and Neck Surgery; 121:381-387, 1999.
Greinwald JH, Bauman NM. “Larsen’s syndrome: Presentation and diagnosis”. Otolaryngology Head and Neck Surgery; 121:845 1999.
Olney DR, Greinwald JH, Smith RJH, Bauman NM. “Laryngomalacia and its treatment”. Laryngoscope; 109:1770-1775, 1999.
Lim AT, Washington AP, Greinwald JH, Lassen LF, Holtel MR. "Effect of Pentoxiphylline on Tympanic Membrane Perforations." Annuals of Otolaryngology-Head and Neck Surgery; 109, 262-266, 2000
Clark P, Greinwald JH, Requena R. Diagnostic puzzler: Endobronchial hemangioma. Journal of Respiratory Diseases ; 2:76,80, 2000.
Scott K, Greinwald JH, Darrow D, Smith RJH. “Endobronchial tumors in children: An uncommon clinical entitiy”. Annuals of Otolaryngology
Greinwald JH, Smith RJH. “Hereditary Hearing Impairment” In Current Therapies in Otolaryngology. Gates GA (ed) 6th ed. Mosby, St. Louis, 1998. pp34-41.
Greinwald JH, Smith RJH. Laryngeal disorders. In Principles and Practice of Pediatrics. Oski FA, DeAngelis CD, Feigin RD, McMillan JA, Warshaw JB (eds). J.B.Lippencott Co, Philadelphia, 1999 pp. 1230-1240.
Greinwald JH, Smith RJH. Langerhans’ cell histiocytosis. In Tumors of the Ear and Temporal Bone. Jackler RK, Driscoll C (eds). Lippencott-Raven Co, Philadelphia, 2000 pp 417-430
Greinwald JH, Cotton RT. Pathophysiology of stridor and airway disease. In Basic Science Review for Otolaryngology. Van De Water TR, Staecker H (eds). Thieme, New York, 1999 (scheduled).
Scott K, Greinwald JH, Darrow D, Smith RJH. “Endobronchial tumors in children: An uncommon clinical entitiy”. Annuals of Otolaryngology Head and Neck Surgery; 110:63-9, 2001.
Carron J, Oberman, J, Greinwald JH, Derkay CS. Effects of simulated gastroesophageal reflux on laryngotracheal reconstruction in rabbits. Archives of Otolaryngology 127:576-80, 2001.
Gessler E, Hart KE, Dunlevy TD, Greinwald JH. The optimal concentration of epinephrine for ear canal injection based on laser doppler flow measurements. Laryngoscope 111:1687-1690, 2001
Holcomb D, Jaffe, D, Greinwald JH, Smith RJ, Bauman NM. “The diagnosis and treatment of C1-C2 rotary subluxation”. Nontraumatic atlantoaxial rotary subluxation in the pediatric otolaryngology patient. A report of four cases. Annual of Otology, Rhinology and Laryngology; 110:1137-40, 2001
Greinwald JH, Hartnick C. The diagnostic evaluation of sensorineural hearing loss in children”. Archives of Otolaryngology 128:84-87, 2002.
Maddern C, Greinwald JH, Hilbert L, Choo DI. Cochlear implantation in children with Auditory Neuropathy. Otology Neurotology 23:163-168, 2002.
Scott KJ, Schroeder AA, Greinwald JH. Ectopic cervical thymus: an uncommon diagnosis in the evaluation of pediatric neck masses. Archives of Otolaryngology. 128:714-717,2002.
Maddern C, Rutter M, Hilbert L, Greinwald JH, Choo DI. Clinical and audiological features in auditory neuropathy. Archives of Otolaryngology 128:1026-1032, 2002.
Giguere CM, Bauman NM, Sato Y, Burke DK, Greinwald JH, Pransky S, Kelley P, Georgeson K, Smith RJ. Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: a prospective multi-institutional trial. Archives Otolaryngology Head and Neck Surgery 128:1137-44, 2002.
Gessler EM, Simko EJ, Greinwald JH. Adult laryngomalacia: An uncommon clinical entity. American Journal of Otolaryngology 23:386-9, 2002.
Merves M, Krane CM, Dou H, Greinwald JH, Menon AG, Choo D. Expression of Aquaporin 1 and 5 in the Developing Mouse Inner Ear and Audiovestibular Assessment of an Aqp5 Null Mutant. Journal of the Association for Research in Otolaryngology 04:264-275, 2003.
Madden C, Halsted M, Benton C, Greinwald J, Choo D. Characterization of EVA in a pediatric population. Otology-Neurotology 24:625-32, 2003.
Lim LHY, Bradshaw JK, Guo Y, Pilipenko V, Madden C, Ingala D, Keddache M, Choo DI, Wenstrup R, Greinwald JH. Genetic heterogeneity in the Midwestern US hearing loss population. Archives Otolaryngology Head and Neck Surgery 129:836-840, 2003.
Madden C, Halstead MJ, Hopkin RJ, Choo DI, Benton C, Greinwald JH. Temporal bone anomalies associated with hearing loss in Waardenburg syndrome. Laryngoscope 113:2035-2041, 2003.
Chadwell JB, Halsted MJ, Choo DI, Greinwald JH, Benton C.. The cochlear cleft. American Journal of Neuroradiology 25:21-24, 2004.
Pilipenko V, Reese A, Choo, DI, Greinwald JH. Genomic organization and expression analysis of the murine Fam3c gene. Gene 335:159-168, 2004.
Li, R, Greinwald, JH, Yang, L, Choo, DI, Wenstrup, RJ and Guan, MX (2004) Molecular analysis of mitochondrial 12S rRNA and tRNASer(UCN) genes in sporadic pediatric subjects with nonsyndromic hearing loss. Journal of Medical Genetics 41:615-20.
Guo Y, Pilipenko V, Lim LH, Dou H, Johnson L, Srisailapathy CR, Ramesh A, Choo DI, Smith RJ, Greinwald JH. Refining the DFNB17 interval in consanguineous Indian families. Molecular Biology Report 31:97-105, 2004.
Dou H, Xu J, Wang Z, Smith AN, Soleimani M, Karet FE, Greinwald JH, Choo D. Co-expression of Pendrin, Vacuolar H+-ATPase {alpha}4-Subunit and Carbonic Anhydrase II in Epithelial Cells of the Murine Endolymphatic Sac. Journal of Histochemistry and Cytochemistry. 52:1377-1384, 2004
Salamone F, Bobbitt B, Myer C, Rutter M, Greinwald J. Bacterial tracheitis reexamined: Is there a less severe manifestation? Otolaryngology Head and Neck Surgery Dec;131(6):871-6, 2004
Preciado D, Lim L, Cohen A, Madden C, Myer D, Ngo C, Bradshaw J, Lawson L, Choo D, Greinwald J. A diagnostic paradigm for childhood idiopathic sensorineural hearing loss. Otolaryngology Head and Neck Surgery Dec;131(6):804-9, 2004
Wang, Q., Li, R., Zhao, H., Yang, L., Han, D., Greinwald, J.H., Young, W.Y. and Guan, M.X (2004) Clinical and molecular characterization of a Chinese patient with auditory neuropathy associated mitochondrial 12S rRNA T1095C mutation. Am J Med Genet A. 2005 Feb 15; 133(1):27-30.
Schmithorst VJ, Holland SK, Ret J, Duggins A, Arjmand E, Greinwald J. Cortical reorganization in children with unilateral sensorineural hearing loss. Neuroreport. 2005 Apr 4;16(5):463-7.
Young WY, Zhao L, Qian Y, Wang Q, Li N, Greinwald JH Jr, Guan MX. Extremely low penetrance of hearing loss in four Chinese families with the mitochondrial 12S rRNA A1555G mutation. Biochem Biophys Res Commun. 2005 Mar 25;328(4):1244-51.
Greinwald, JH, Kelly, KE, Tami, TA. Temporal Bone and Skull Base Trauma.In Neurotology, Second Edition, edited by R.K. Jackler and D.E. Brackman,Elsevier Mosby, Philadelphia, PA, Chapter 63, 2005.
Greinwald JH, Kelly K, Tami T. Temporal bone and skull base trauma. In Neurotology. Jackler RK, Brackmann DE (eds). Mosby, St. Louis, 2004

Research:

A comparison in the efficacy of uvulopalatoplasty by eletrocautery vs carbon dioxide laser
The effect of local epinephrine on cutaneous blood flow in the external ear
The use of anti-oxidants in external ear avulsions
Hereditary hearing impairment work performed under the grant of Dr. RJH Smith
Multicenter trial of Picibinal sclerotherapy for lymphangiomas in children
Gastroesophageal reflux and laryngotracheal Reconstruction
Identification and characterization of the DFNB17 gene
The molecular basis for aminoglycoside ototoxicity
The implementation of a deafness gene gene chip for newborn sensorineural hearing loss
Clinical and biochemical study of mutations In the tRNASer(UCN) gene

Hospital Appointments:

Partial List of Presentations:

"The treatment of lymphangiomas in children : An update of Picibanil (OK-432) sclerotherapy". Presented at the annual meeting of the American Society of Pediatric Otolaryngology, May, 1998.
"An update of the Iowa experience for the treatment of life-threatening hemangiomas with interferon alpha-2a". Presented at the annual meeting of the American Society of Pediatric Otolaryngology, May, 1998.
“The treatment of hemangiomas, lymphangiomas and venous malformations”. Instructional course presented at the annual meeting of the American Academy of Otolaryngology-Head and Neck Surgery, September, 1998, 1999.
Instructor in “Endoscopic foreign body retrieval laboratory” at The Central Atlantic Brochoesophagolgy Symposium, Medical College of Virginia, October, 1998.
“Molecular Genetics in Otolaryngology”. Combined Navy-EVMS Otolaryngology Grand Rounds, January 1999.
“Update in ENT” at the annual meeting of the military section of the American Academy of Pediatrics, March 1999.
“A tale of two tumors: hemangiomas and lymphangiomas” at the 24th annual MajGen Paul H. Streit Memorial Otolaryngology Seminar, Uniformed Services University of the Health Science, March 1999.
“Cochlear expressed genes in the DFNB7/11 region of chromosome 9q.” The annual meeting of the Society of Pediatric Otolaryngology, Palm Desert , CA, April 1999.
Lecturer at The Central Atlantic Brochoesophagolgy Symposium, Medical College of Virginia, October, 1999.
“An update on the use of Picibanil in the treatment of lymphangiomas” Vascular anomalies 2000, New York, NY, April 2000.
“Pediatric Sinusitis” University of Cincinnati Department of Otolaryngology Primary Care Symposium, Cincinnati, OH, November, 2000
“Ectopic thymus: An uncommon cause of cervical masses”. The annual meeting of the Society of Pediatric Otolaryngology, Scottsdale, Az, May 2001.
“The audiological and clinical characteristics of auditory neuropathy”. The annual meeting of the Society of Pediatric Otolaryngology, Scottsdale, Az, May 2001.
"Cochlear implantation in children with auditory neuropathy". The annual meeting of the American Otologic Society, Palm Springs, AZ, May 2001
"Towards an understanding of the DFNB17 gene". The 25th annual Midwinter Research meeting of the Association for Research in Otolaryngology, St. Petersburg, FL, Feb 2002.
"Mutations in the connexin 26 gene among Bangladeshi and Americans with nonsyndromic hearing loss." The 25th annual Midwinter Research meeting of the Association for Research in Otolaryngology, St. Petersburg, FL, Feb 2002.
“Molecular Biology’” University Hospital Grand Rounds, Cincinnati, Ohio. April 2002.
"Heterogeniety of GJB2 mutations in the Midwestern US." The annual meeting of the American Society of Pediatric Otolaryngology, Boca Raton, FL, May 2002.
"Rehabilitation in Auditory Neuropathy." The annual meeting of the American Society of Pediatric Otolaryngology, Boca Raton, FL, May 2002.
Enlarged Vestibular Aqueduct Syndrome in a pediatric population. The annual meeting of the American Society of Otology, Boca Raton, FL, May 2002.
“Temporal Bone Trauma” University Hospital Grand Rounds, Cincinnati, Ohio, August 2002.
"Current trends in the evaluation of children with sensorineural hearing loss." The 2nd Regional Infant Hearing Symposium, Cincinnati, OH, Sep 2002.
"Current trends in the treatment of lymphangiomas." Annual meeting of the American College of Surgeons, San Francisco, CA, Oct 2002.
"Mutations in the GJB2 gene among Bangladeshi with nonsyndromic hearing impairment." The 52nd annual meeting of the American Society of Human Genetics, Baltimore, MD, Oct 2002.
“Enlarged Vestibular Aqueduct Syndrome,” University Hospital Grand Roungs, Cincinnati, Ohio November 2002.
“Redefining the DFNB17 Interval in Consanguineous Indian Families”, Association for Research in Otolaryngology, Daytona Beach, Florida, February 2003.
“New Horizons in Pediatric Hearing Loss” AAO-HNSF Annual Meeting in Orlando, Florida, September 2003
“Novel Diagnostic and Therapeutic Methods in Pediatric Hearing Loss,” Cincinnati Children’s Hospital Pediatric grand rounds, Cincinnati, Ohio September 2003.
“Auditory Neuropathy” Cincinnati Children’s Hospital Grand Rounds, Cincinnati, Ohio, December 2003.
“Identification of the DFNB17 gene,” Association for Research in Otolaryngology, Daytona Beach, Florida. February 2004.
“Maternally inherited aminoglycoside-induced and non-syndromic deafness associated with the novel C1-494-T mutatin in the mitochondrial 12S rRNA gene in a large Chinese family’” Association for Research in Otolaryngology, Daytona Beach, Florida. February 2004.
“The Treatment of Lymphangiomas in Children,” B. C. Children’s Hospital as invited speaker. Vancouver, Canada April 2004.
“The Biology of Cholesteotomas,” B. C. Children’s Hospital as invited speaker. Vancouver, Canada April 2004.
“What is new in the diagnosis of sensorineural hearing loss (SNHL),” B. C. Children’s Hospital as invited speaker. Vancouver, Canada April 2004.
“Clinical relevance of head and neck anatomy and embryology” University of Cincinnati, Cincinnati, Ohio. April 2004.
“Audiometric, Clinical and Educational Findings in a Pediatric Symptomatic Congenital Cytomegalovirus.” Combined Otolaryngology Spring Meeting, Phoenix, Arizona, May 2004.
“Identification of the DFNB17 Gene” Combined Otolaryngology Spring Meeting, Phoenix, Arizona, May 2004.
“Sensorineural hearing loss in children.” Mississippi Society of Otolaryngology, Jackson, Mississippi, September 2004
“Auditory neuropathy in children.” Mississippi Conference of Audiologist and Speech and Language Pathologists, Jackson, Mississippi, September 2004.
8th Annual Midwest Neonatology Critical Care Symposium in Covington, Kentucky, “The Diagnosis of Newborn Hearing Loss: A Changing Paradigm”- November 6, 2004

Awards:

1990 - National Defense Medal
1991 - Expert Medals in Pistol and Rifle
1991 - Letter of Commendation, Commanding General, 2nd Marine Air Wing
1991 - Navy Expeditionary Medal
1994 - Best Paper Award in Category 3 @ the Annual Naval Medical Center, Portsmouth Research Competition
1994 - Best Paper Award at the Annual Meeting of the Virginia Society of Otolaryngology
1994 - 99% score on the National Inservice Exam
1994 - Navy Achievement Medal
1995 - Best Poster A - (Resident) at the Annual Naval Medical Center Portsmouth Research Competition
1996 - Armed Forces Commendation Medal
1997 - Best Poster A - at the 12th annual meeting of the American Society of Pediatric Otolaryngology (Basic Science)
1999 - William P. Potsic A - Basic Science Research A - at the 14th annual meeting of the American Society of Pediatric Otolaryngology
1999 - 1st place award, category 2, at the Annual Naval Medical Center, Portsmouth Research Competition