Simon L Newman, PhD Professor of Medicine College of Medicine University of Cincinnati

Practice Address:

Infectious Disease Center - Holmes Hospital
Eden and Bethesda Avenues
Cincinnati, OH 45267-0405

Education:

• Emory University: B.A.
• University of Alabama: M.S.
• University of Alabama Medical Center: Ph.D.

Associations:

• American Association for the Advancement of Science
• American Society for Microbiology
• American Association of Immunologists

Partial List of Publications:

• Chaaturvedi, S, and SL Newman. 1997. Modulation of the effector function of human macrophages for Histoplasma capsulatum by HIV-1. Role of the envelope glycoprotein gp120. J. Clin. Invest. 100:1465-1474.
• Klein BS, LH Hogan, and SL Newman. Cell surface molecules of Blastomyces dermatitidis. ASM News. 1997; 63: 140-145.
• Newman SL, L Gootee, C Kidd, CM Ciraolo, and R Morris. Activation of human macrophage fungistatic activity against Histoplasma capsulatum upon adherence to type I collagen matrices. J. Immunol. 1997; 158: 1779-1786.
• Klein BS, and SL Newman. Role of cell-surface molecules of Blastomyces dermatitidis in host-pathogen interactions. Trends in Microbiology. 1996; 4: 246-251.
• Chaturvedi V, B Wong, and SL Newman. Oxidative killing of Cryptococcus neoformans by human neutrophils. Evidence that fungal mannitol protects by scavenging reactive oxygen intermediates. J. Immunol. 1996; 156:L 3836-3840.
• Newman SL, L Gootee, V Stroobant, H van der Goot, and JR Boelaert. Inhibition of the growth of Histoplasma capsulatum yeast cells in human macrophages by the iron chelator VUF 8514 and comparison with deferoxamine. Antimicrob. Agents Chemother. 1995; 29: 1824-1829.
• Chaturvedi D, P Frame, and SL Newman. Macrophages from human immunodeficiency virus-positive persons are defective in host defense against Histoplasma capsulatum. J. Infect. Dis. 1995; 171: 320-327.
• Newman SL, S Chaturvedi, and BS Klein. The WI-1 antigen of Blastomyces detmatitidis yeasts mediates binding to human macrophage CD11b/CD18 (CR3) & CD14. J. Immunol. 1995; 154: 753-761.
• Klein BS, S Chaturvedi, LH Hogan, JM Jones, and SL Newman. Altered expression of surface protein WI-1 in genetically related stains of Bastomyces dermatitidis that differ in virulence regulates recognition of yeasts by human macrophages. Infect. Immuno. 1994; 154: 753-761.
• Newman, SL, L Gootee, G Brunner, and GS Deepe. Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of iron and therapeutic in a murine model of histoplasmosis. J. Clin. Invest. 1994; 93: 1422-1429.

Research:

• NIH, NHLBI, HL-55948. Interaction of H. capsulatum with alveolar macrophages. SL Newman, Principal Investigator. 50% effort. $145,073 annual direct costs for 03 year. 9/30/95-8/31/00. Total direct costs = $714,357.
• NIH, NIAID, AI-37639. Interaction of H. capsulatum with macrophages and PMN. SL Newman, Principal Investigator. 4013 annual direct costs for 02 year. 7/1//96-6/30/01. Total direct costs = $714,357.
• NIH, NIAID, AI-35681. Molecular Pathogenesis of Bastomycosis. B. Klein, Principal Investigator. S. Newman, Co-Investigator, 5% effort. $6,866 annual direct costs for 04 year (subcontract figure). 12/01/94-11/30/98; total direct costs = $70,419 (subcontract figure).

Hospital Appointments: