CV: Elliott D. Crouser MD

Elliott D. Crouser, MD
Associate Professor
Pulmonary, Allergy, Critical Care & Sleep Medicine
Department of Internal Medicine
College of Medicine
The Ohio State University

Answers questions in the following forums:

NetWellness Articles associated with this Author:

Article Name Forum

Overview
Sarcoidosis

	Article Name	Forum
	Overview	Sarcoidosis

Education:

1979 - 1983. Oberlin College, Oberlin, Ohio. B.A. Geology/Chemistry

Post Graduate Training:

1985 - 1989. Medical College of Ohio, Toledo, Ohio. MD

Licensure or Certification:

Board Certification, Critical Care Medicine (since 1995)
Board Certification, Pulmonary Medicine (since 1994)
Board Certification, Internal Medicine (since 1992)
Medical Licensure, State Medical Board of Ohio (since 1989)

Affiliations:

2006- Present. Associate Professor of Medicine, The Ohio State University Medical Center
2006-Present. Co-Director, Institute of Mitochondrial Biology, The Ohio State University Medical Center.
2006-Present.Interim Director of Research, Critical Care Center, The Ohio State University Medical Center
2004-Present. Section Chief, Division of Pulmonary & Critical Care Medicine, The Ohio State University Hospital East
2003-Present. ICU Director, The Ohio State University East Hospital
2002-Present. Chair, Code Blue Continuous Improvement Committee, The Ohio State University Medical Center
2000-Present. HLRI Investigator, The Dorothy M. Davis Research Institute, Columbus, OH
1999-Present. Director, The Ohio State University Medical Center Sarcoidosis Clinic
1998-Present. Assistant Professor of Medicine, Division of Pulmonary and Critical Care Medicine, The Ohio State University Medical Center
1992-Present. Pulmonary & Critical Care Medicine. Ohio State University Medical Center, Columbus, Ohio
1989-Present. Internal Medicine. Ohio State University Medical Center, Columbus, Ohio

Partial List of Publications:

Rosenbaum JT, Pasadhika S, Crouser ED, Harrington CA, Choi D, Smith JR, Braziel RM, Vance EE, Planck SR. Hypothesis: Sarcoidosis is a STAT1-mediated disease. Clin Immunol 2009 (Epub ahead of print).
Crouser ED, Culver DA, Knox KS, Julian MW, Shao G, Macre JE, Liyanarachchi S, Wewers MD, Gavrilin M, Ross P, Abbas A, Eng C. Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators in pulmonary sarcoidosis. Am J Respir Crit Care Med 2009; 179: 929-38.
Knoell DR, Julian MW, Bao S, Besecker B, Macre JE, Leikauf G, DiSilvestro R, Crouser ED. Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis. Crit Care Med 2009; 37:1380-8.
Crouser ED, Shao G, Julian MW, Macre JE, Tridandapani S, Shadel GS, Huang Q, Wewers MD. Monocyte Activation by Necrotic Cells is Promoted by Mitochondrial N-Formyl Proteins and Formyl Peptide Receptors. Crit Care Med 2009; 37: 2000-9.
Pompili V, Crouser ED. Stem cell therapy: A “magic bullet” for cardiomyopathies? Crit Care Med 2009; 37: 1487-9 (In Press)
Ali NA, O’Brien JM, Hoffmann SP, Phillips G, Garland A, Finley JC, Almoosa K, Hejal R, Wolf KM, Lemeshow S, Connors AF, Marsh CB, [Midwest Critical Care Consortium (including Crouser, ED)]. Acquired weakness, handgrip strength, and mortality in critically ill patients. Am J Respir Crit Care Med 2008; 178:261-8.
Exline MC, Crouser ED. Mitochondrial mechanisms of sepsis-induced organ failure. Frontiers in Bioscience 2008; 13:5030-41.
Crouser ED, Exline M, Knoell D, Wewers MD. Sepsis: links between pathogen sensing and organ damage. Current Pharmaceutical Design 2008; 14:1840-52.
Hussain SR, Lucas DM, Johnson AJ, Lin TS, Bakaletz AP, Dang VX, Viatchenko-Karpinski S, Ruppert AS, Byrd JC, Kuppusamy P, Crouser ED, Grever MR. Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium. Blood 2008;111:3190-9.
Crouser ED. Suppression of monocyte metabolism by septic plasma: revisiting the concept of “blood poisoning”. Crit Care Med 2007; 35:2856-7.
Hoffmann S, Crouser ED. Mitochondrial mechanisms of organ dysfunction during sepsis. Advances in Sepsis 2007; 6:2-9.
Wynbrandt J, Crouser ED. Transformation of Pulmonary Histoplasmosis to Sarcoidosis. Respir Med 2007 Apr;101(4):863-4. Epub 2006 Oct 2.
Crouser ED, Cook CH, Julian MW, Struck J, Huff JE. Carbamoyl Phosphate Synthase-1: A Marker of Mitochondrial Damage and Depletion in the Liver During Sepsis. Crit Care Med 2006; 34:2439-46.
Crouser ED, Julian MW, Huff JE, Mandich D, Green-Church K. A proteomic analysis of liver mitochondria during acute endotoxemia. Intensive Care Med 2006; 32:1252-62.
Joshi MS, Julian MW, Huff JE, Bauer JA, Xia Y, Crouser ED. Calcineurin Regulates Myocardial Function during Acute Endotoxemia. Am J Respir Crit Care Med 2006, 173:999-1007.
Gadd ME, Broekemeier KM, Crouser ED, Graff G, Pfeiffer DR. Mitochondrial iPLA2 activity modulates the release of cytochrome c from mitochondria and influences the permeability transition. J Biol Chem 2006; 281: 6931-9.
O’Brien JM, Crouser ED. 35th Critical Care Congress of the Society of Critical Care Medicine (SCCM). San Francisco, CA, USA, Jan 7-11, 2006. Advances in Sepsis 2006; 5: 120-2.
Fahy RJ, Crouser ED. Summary of the International Conference of the American Thoracic Society. San Diego, CA, USA, 20-25 May, 2005. Advances in Sepsis 2005; 4: 154-6.
Crouser ED. Respiratory failure during critical illness: are mitochondria to blame? Am J Respir Crit Care Med. 2005;172(7):793-7.
Crouser ED. Is cell death a prerequisite for cardiac dysfunction during sepsis? Crit Care Med 2005;33(5):1160-2.
Crouser ED. Redefining the roles of apoptosis pathways during sepsis. Crit Care Med 2005;33(3):670-2.
Crouser ED, Cook C, Julian M, Huff J. Impaired mitochondrial function and structure in the liver during subacute sepsis. Proceedings of the 6th World Congress on Trauma, Shock, Inflammation and Sepsis. 2004;199-204.
Crouser ED. Mitochondrial Dysfunction in Septic Shock and Multiple Organ Dysfunction Syndrome. Mitochondrion. 2004;4(5-6):729-41.
Crouser ED. Therapeutic Benefits of Antioxidants During Sepsis: Is Protection Against Oxidant-Mediated Tissue Damage Only Half the Story? Crit Care Med 2004;32:589-90.
Lucarelli MR, Shirk MB, Julain MW, *Crouser ED. Toxicity of Food Dye FD&C Blue No. 1 in critically ill patients”. Chest 2004;125;793-5. *Communicating author
Crouser ED, Julian MW, Huff JE, Pfeiffer DR, Joshi MS, Bauer JA, Gadd ME, Wewers MD. Abnormal Permeability of Inner and Outer Mitochondrial Membranes Contributes to Mitochondria Dysfunction in the Liver During Acute Endotoxemia. Crit Care Med 2004;32:478-88.
Crouser ED, Gadd ME, Julian MW, Huff JE, Broekemeier KM, Robbins KA, Pfeiffer DR. Quantitative comparison of cytochrome c release and outer membrane disruption in rat liver mitochondria. Anal Biochem 2003;317:67-75.
Crouser ED, Julian MW, Joshi MS, Bauer JA, Wewers MD, Hart JM, Pfeiffer DR. Cyclosporin A Ameliorates Mitochondrial Ultrastructural Injury in the Ileum During Acute Endotoxemia. Crit Care Med 2002;30:2722-8.
Crouser ED, Julian MW, Blaho DV, Pfeiffer DR. Endotoxin-Induced Mitochondrial Damage Correlates with Impaired Respiratory Activity. Crit Care Med 2002;30:276-84.
Broekemeier KM, Iben JR, LeVan EG, Crouser ED, Pfeiffer DR. Pore Formation and Uncoupling Initiate a Ca2+-independent degradation of mitochondrial phospholipids. Biochemistry 2002;18:7771-80.
Backer LB, Weisfeldt ML, Weil MH, Budinger T, Carrico J, Kern K, Nichol G, Shechter I, Traystman R, Webb C, Wiedemann H, Wise R, Sopko G and participants in the “PULSE Workshop” (including Crouser, ED). The PULSE Initiative: Scientific Priorities and Strategic Planning for Resuscitation Research and Life Saving Therapies. Circulation 2002; 105:2562-70.
Weil MH, Becker L, Budinger T, Kern K, Nichol G, Shechter I, Traystman R, Wiedemann H, Wise R, Weisfeldt M, Sopko G and participants in the “PULSE Workshop” (including Crouser, ED). Workshop Summary Report: Post-Resuscitative and Initial Utility in Life Saving Efforts (PULSE). Circulation 2001; 103:1182-4.
Joshi MS, Crouser ED, Julian MW, Schanbacher BL, Bauer JA. Digital Imaging Analysis for the Study of Endotoxin-Induced Mitochondrial Ultrastructure Injury. Anal Cell Pathol 2000;21(1):41-8.
Crouser ED, Julian MW, Weinstein DM, Fahy RJ, Bauer JA. Endotoxin-induced ileal mucosal injury and nitric oxide dysregulation are temporally disassociated. Am J Resp Crit Care Med 2000;161:1705-12.
Crouser ED, Julian MW, Dorinsky PM. Ileal VO2-DO2 Alterations Induced by Endotoxin Correlate with Severity of Mitochondrial Injury. Am J Resp Crit Care Med 1999;160:1347-53.

Research:

07/01/09-06/30/11. R21 AI083912, Crouser (PI). NIH/NIAID. Dendritic Cell Activation by Mitochondrial Transcription Factor A The role of mitochondrial transcription factor A in the pathogenesis of dendritic cell-mediated inflammation arising in the context of acute cell and tissue damage (sterile inflammation) will be investigated. There is no overlap with the proposed investigations.
04/01/08-03/31/10. Foundation for Sarcoidosis Research Partnership Grant, Crouser (PI). American Thoracic Society/Foundation for Sarcoidosis Research Modulation of Pulmonary Sarcoidosis by Nicotinic Acetylcholine Receptors The role of ?7 acetylcholine receptors in the pathogenesis of sarcoidosis will be determined in these investigations. There is no overlap with the proposed investigations.
9/30/2000-8/31/2010. NIH 5T32 HL 007946, Mark D. Wewers (PI). NIH NHLBI. Molecular Mechanisms of Lung Inflammation. This is a postdoctoral training grant focusing on diseases of the lung. Role: Preceptor
9/30/2007-8/31/2012. NIH 5T32 HL 007946, Mark D. Wewers (PI), Crouser (Co-I). NIH NHLBI. Molecular Mechanisms of Lung Inflammation. This is a postdoctoral training grant focusing on diseases of the lung. Role: Preceptor and Mentor of Meghan McCullers, T32 recipient (03/01/08-02/28/10).

Awards:

2000-03. Parker B. Francis Fellowship in Pulmonary Research $120,000 (Declined for KO8 Grant)
2001-04. American Lung Association, Career Investigator Award, $105,000
2000-01. Davis Families Foundation Scholarship Award, $18,000
2000-05. National Institutes of Health, Career Development Award (K08), $632,475
2000. Invited participant National Institutes of Health, Post-Resuscitative and Initial Utility in Life Saving Efforts (PULSE) Workshop; Leesburg, VA, June 29-30, 2000. A summary of the proceedings are published in Circulation 2001;103:1182-4 and Circulation 2002; 105: 2562-70.
1999-01. American Heart Association, Beginning Grant-in-Aid $60,000 (Second year of funding declined due to funding overlap with AHA Grant-in-Aid)

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What Is Sarcoidosis?