CV: C. Lawrence Kien MD, PhD

C. Lawrence Kien, MD, PhD
Professor, Department of Pediatrics
Nationwide Children’s Hospital
College of Medicine
The Ohio State University

Practice Address:

Room W209, Children's Hospital
700 Children's Drive
Columbus, OH 43205

Education:

Massachusetts Institute of Technology, Cambridge, Massachusetts, Department of Nutrition and Food Science, Ph.D. Nutritional Biochemistry and Metabolism, 1977
University of Cincinnati, Cincinnati, Ohio, College of Medicine, M.D., 1972
Duke University, Durham, North Carolina, B.S. Zoology, 1968

Post Graduate Training:

Montreal Children's Hospital, Montreal, Quebec, Canada, Intern (Pediatrics), 1972-73
Montreal Children's Hospital, Montreal, Quebec, Canada, Resident (Pediatrics), 1973-74
The Children's Hospital Medical Center, Boston, Massachusetts, Affiliating Resident, 1974-75
Massachusetts General Hospital and Shriners Burns Institute, Boston, Massachusetts, Fellow in Clinical & Research Pediatrics, 1974-77
The Children's Hospital Medical Center, Boston, Massachusetts, Fellow in Medicine (Gastroenterology and Clinical Nutrition), 1976-77
Mass. Institute of Technology, Dept. of Nutrition & Food Science, Postdoctoral Fellow, 1977

Licensure or Certification:

Ohio
American Board of Pediatrics, 1977
American Board of Nutrition, 1981

Associations:

American Physiological Society, 1978-
American Society of Parenteral and Enteral Nutrition, 1978-
Sigma Xi, 1981
Milwaukee Pediatric Society, 1981-1984
Society for Pediatric Research, 1981-
American Society for Nutritional Sciences, 1983-
American Society for Clinical Nutrition, 1983-
Monongalia Medical Society, 1985-1987
Fellow, American Academy of Pediatrics, 1987-
Fellow, American College of Nutrition, 1987-
Central Ohio Pediatric Society, 1988-
North American Society for Pediatric Gastroenterology and Nutrition, 1991-
American Pediatric Society, 1993-
European Society for Pediatric Research, 1994-
North American Association for the Study of Obesity, 1995-
American Association for the Advancement of Science, 1995-
Section on Perinatal Pediatrics, American Academy of Pediatrics, 1996-

Partial List of Publications:

Schuster, DP; Kien, CL; Osei, K: The differential impact of obesity on glucose metabolism in African American and Caucasian adolescents. Amer J Med Sci 316: 361-367, 1998.
Kien, CL: Pediatrics and neonatology. In: Nutrition Support and Care: A guide for clinicans (ED. L. Flancbaum). Marcel Dekker, Inc. (In Press, 1998)
Kien, CL; Ailabouni, AH; Murray, AD; Powers, PA; McClead, RE; Kepner, J: Technical Note: Piglet Model for Studying Nutrient Assimilation by the Intestine and Colon. J Anim Sci, 75: 2161-2164, 1997.
Kien, CL; Murray, RD; Ailabouni, AH; Habash, DL; Powers, PA: Measurement of the Rate of Entry of Intact Colon-Derived Lactose into the Circulation: A Model for Assessing Gut Uptake of Molecules Not Endogenously Synthesized. J Ped Gastro Nutr, 25:68-73, 1997.
Horswill, CA; Zipf, WB; Kien, CL: Measuring energy costs of leisure activity in adolescents using a carbon dioxide breath test. Med Sci Sports Exer 29: 1263-1268, 1997.
Tsao, CY; Luquette, M; Rusin, J.A.; Herr, G.M.; Kien, CL; Morrow, G: Leigh Syndrome, Cytochrome C Oxidase Deficiency and Infantile Spasms. Clinical EEG 28:214-217, 1997.
Horswill, CA; Zipf, WB, Kien CL; Kahle, EB: Insulin's contribution to growth in children and the potential for exercise to mediate insulin's action. In Pediatric Exercise Science, Vol. 9, pp.18-32, Feb. 1997.
Kien, CL; McClead, RE; Cordero,JR., L: Effects of lactose intake on lactose digestion in preterm infants. Annual meeting of American Gastroenterological Association, Washington DC, May 12, 1997, Gastroenterology, 112; A885.
Murray, RD; Ailabouni, A; Heitlinger, LA; Li BUK; McClung, HJ; Powers, P; Kien, CL: Galactose-containing carbohydrates are preferentially absorbed in the neontal pig colon. Pediatr Res, 39: 656-660, 1996.
Kien, CL; McClead, RE; Cordero, Jr., L: In Vivo Lactose Digestion in Preterm Infants. Am J Clin Nutr, 64: 700-705, 1996.
Kien, CL; Zipf, WB; Horswill, CA; Denne, SC; McCoy, KS; O'Dorisio, TM: Effects of feeding on protein turnover in healthy children and in children with cystic fibrosis. Am J Clin Nutr, 64: 608-614, 1996.
Kien, CL; McClead, RE: Estimation of Carbon Dioxide Production in Enterally Fed Preterm Infants Using an Isotope Dilution Stable Tracer Technique. JPEN, 20: 389-393, 1996.
Kien, CL; Murray, RD; Ailabouni, A: Powers, P; Kepner, J; Powers, L; Brunengraber, H: Stable Isotope Model for Assessing Production of Short Chain Fatty Acids from Colon-Derived Suagr. J Nutr, 126: 3069-3076, 1996.
Kien, CL: Digestion, absorption, and fermentation of carbohydrates in the newborn. In: Neu, J. (Ed): Clinics in Perinatology - Neonatal Gastroenterology, W. B. Saunders Company, Philadelphia, Pennsylvania. Volume 23, pp. 211-228, 1996.
Kien, CL; Horswill, CA; Zipf, WB; McCoy, KS; O'Dorisio, TM: Elevated Hepatic Glucose Production in Children with Cystic Fibrosis. Pediatr Res, 37: 600-605, 1995.
Horswill, CA; Kien, CL; Zipf, WB: Energy Expenditure in Adolescents During Low Intensity, Leisure Activities. Med Sci Sports Exer, 27: 1311-1314, 1995.
Coggan, AR; Swanson, SC; Mendenhall, LA; Habash, DL; Kien, CL: Effect of endurance training on hepatic glycogenolysis and gluconeogenesis during prolonged exercise in men. AJP: Endocrinol. Metab. 31: E375-E383, 1995.
Kien, CL; Murray, RD; Knerr, TL; McClead, RE; Cordero, Jr, L: A Portable Device for Estimating the Rate of Carbon Dioxide Production in Preterm Infants. Biol. Neonate, 67: 340-345, 1995.
Powers, L; Osborn, MK; Yang, D; Kien, CL; Murray, RD; Beylot, M; Brunengraber, H: Assay of the Concentration and Stable Isotope Enrichment of Short-Chain Fatty Acids by Gas Chromatography/Mass Spectrometry. J Mass Spectrom. 30:747-754, 1995.
Horswill, CA; Kien, CL; Zipf, WB; McCoy, KS: Feeding-Induced Changes in Energy Expenditure in Children with Cystic Fibrosis. JPEN, 18:497-502, 1994.
Kien, CL; McClead, RE; Kepner, J; Grotjohn, K: Comparison of Methods for Estimating Fecal Carbohydrate Excretion in Premature Infants. Journal of Pediatric Gastroenterology and Nutrition, 17:276-282, 1993.
Coggan, AR; Habash, DL; Mendenhall, LA; Swanson, SC; Kien, CL: Isotopic Estimation of Carbon Dioxide Production During Exercise Before and After Endurance Training. J Appl Physiol, 75(1):70-5, 1993.
Kien, CL: "Carbohydrates" In Tsang, R, Lucas, A, Uauy, R, and Zlotkin, S. (Eds.): Nutritional Needs of the Preterm Infant. Scientific Basis and Practical Guidelines, Patterson, NY, Caduceus Medical Publishers, Inc., pp 47-63, 1993.
Kien, CL; Kepner, J; Grotjohn, DA; Gilbert, MM; McClead, RE: Efficient Assimilation of Lactose Carbon in premature Infants. Journal of Pediatric Gastroenterology and Nutrition 15:253-259, 1992.
Kien, CL; Kepner, J; Grotjohn, K; Ault, K; McClead, RE: Stable Isotope Model for Estimating Colonic Acetate Production in Premature Infants. Gastroenterology 102: 1458-1466, 1992.
Kien, CL; Ault, K; McClead, RE: In Vivo Estimation of Lactose Hydrolysis in Premature Infants Using a Dual Stable Tracer Technique. Am J Physiol (Endocrinol Metab) 263:E1002-E1009, 1992.
Kien, CL: Nutrition Q and A. Pediatric Directions Spring/Summer pp 18-21, 1992.
Leichty, EA; Denne, SC; Lemons, JA; Kien, CL: Effects of glucose infusion on leucine tranamination and oxidation in the ovine fetus. Pediatric Research 30:423-429, 1991.
Zipf, WB; Kien, CL; Horswill, CA; McCoy, KS; O'Dorisio, T; Pinyerd, BL: Effects of Tolbutamide on Growth and Body Composition of Nondiabetic Children with Cystic Fibrosis. Pediatric Research 30:309-314, 1991.
Kien, CL: Obesity: "Obesity: Update on Metabolic Etiologies" Peptide Therapy: Index and Reviews Volume III, No. 1; pp.14-15, 1991.
Kien, CL; Liechty, EA; Mullett, MD: Contribution of lower molecular weight compounds to the fecal excretion of carbohydrate energy in premature infants. Gastroenterology 1990; 99:165-174.
Kien, CL: A Metabolic Bed for Collecting Excreta in Premature Infants: J Pediatr Gastroenterol Nutr 10:478-481, 1990.
Kien, CL; Leichty, EA; Mullett, MD: Effects of Lactose Intake on Nutritional Status in Premature Infants. J Pediatrics 116:446-449, 1990.
Kien, CL; Chang, EH; Murray, RD; Ailabouni, A; Kepner, J: Measurement of Stable Isotopic Enrichment of Underivatized Acetate by Gas Chromatography/Mass Spectrometry: Application to in vivo Estimation of Acetate Product. Biomedical and Environmental Mass Spectrometry 19:554-558, 1990.
Kien, CL: Colonic Fermentation of Carbohydrate in the Premature Infant: Possible Relevance to Necrotizing Enterocolitis. J Pediatrics 117:S52:S58, 1990.
Kien, CL: Current Controversies in Nutrition. Current Problems in Pediatrics. Volume 20, No. 7; pp.355-408, 1990.
Kien, CL: Pathophysiology of Cancer Cachexia. In: Pochedly, C. (ed): Neoplastic Diseases of Childhood. Harwood Publishers, Philadelphia, Pennsylvania. Volume 2, pp 1397-1409, 1990.
Kien, CL; Horswill, CA; Zipf, WB; McCoy, KS; Denne, SC: Splanchnic uptake of leucine in healthy children and in children with cystic fibrosis. Ped Res, (In press, 1999)
Kien, CL; Murray, RD; Qualman, SJ; Marcon, M: Lactulose feeding in piglets: A model for persistent diarrhea and colitis induced by severe sugar malabsorption. Dig Dis Sci (Accepted with revisions) 1999

Research:

Study of the effect of carbohydrate malabsorption on colon structure, cell kinetics, and function
Exogenous and endogenous production of butyric acid
Rates of oxidation of oleic acid and palmitic acid
Effects of an after-school program for middle school students on moderate physical activity
Effects of a lunch-time nutrition education program on selection and consumption of fruits, vegetables, and dairy products in elementary school children
Study of Helicobacter Pylori infection in children and effects on gastric urea hydrolysis

Hospital Appointments:

The Ohio State University Hospital, Columbus, Ohio; Medical Staff, Courtesy, Pediatrics, 1988-
Comprehensive Cancer Center Associate, Cancer Chemoprevention Program; Member, 1996-
Children's Hospital, Columbus, Ohio; Medical Staff, Sections of Nutrition (Chief) and Gastroenterology, 1988-
Children's Hospital, Columbus, Ohio; Medical, Co-Director, Nutrition Support Team, 1988-

Grants:

NIH M01 RROO034 "General Clinical Research Center" Associate Program Director, 7.5% effort, July 1992 - November 2001. ($7,183,692)
NICHD (Co-Investigator) "Pediatric Pharmacology Research Unit", 3% effort, November 1993-October 1998. ($1,186,296)
Children's Hospital Research Foundation "Nutrition Research Program", 5% effort, January 1998-December 1998. ($69,332)
Crohn's & Colitis Foundation of America, Inc. "Colitis Induced by Carbohydrate Malabsorption", 20% effort, January 1998-December 1999. ($183,998)

Partial List of Presentations:

"Pediatric Obesity", Henry Ford Hospital, Detroit, Michigan, April 30, 1998.
"Prebiotic, probiotic, and antibiotic effects of malabsorbed sugar", INSERM, Hopital Ste Lazare, Paris, France, September 12, 1996.
"Nutritional impact of intestinal malabsorption of sugar", Centre de Pediatrie, Gatien de Clocheville, Tours, France, September 9, 1996.
"Nutritional impact of the intestinal malabsorption of sugar", Children's Hospital of Michigan, Detroit, MI, July 31, 1996.
"Obesity", Ohio Department of Health "Toward the Year 2000: Improving Women's Health in Ohio", Columbus, Ohio, September 22, 1995.
"Manifestations of Nutritional Deficiencies". Denver Children's Hospital (Grand Rounds), April 14, 1995.
"Proposals to assess the relationship between and obesity and lipid oxidation". University of Colorado Medical Center (Nutrition Seminar), April 13, 1995.
"Dual Isotopic Models for Estimating the Rate of Formation of Short Chain Organic Acids from Fermentation of Sugar". Ross Laboratories, Columbus, Ohio, April 5. 1995.
"Models for assessing the metabolic fate of intact lactose absorbed from the colon", Second World Conference on Stable Isotopes in Nutritional and Metabolic Research, Rotterdam, The Netherlands, July 8, 1994.
"Direct evidence for deficient in vivo lactose digestin in preterm infants", Second World Conference on Stable Isotopes in nutritional and Metabolic Research, Rotterdam, The Netherlands, July 7, 1994.
"Lactose metabolism and its role in neonatlal nutrition", Case Western Reserve University (Seminar for Felllows in Neonatology), November 18-19, 1993.
"Failure to Thrive", Fourth Annual Nutrition Symposium, Zanesville-Muskingum Co. Health Department and the Ohio Department of Health, Muskingum College, New Concord, Ohio, November 16, 1993.
"Nutritional Support of the Patient with Cystic Fibrosis: Newer Concepts", Annual Nutrition Support Conference (Symposium), Ohio Society for Parenteral and Enteral Nutrition and Cleveland Clinic, Cleveland, OH, October 22-23, 1993.
"Nutritional Deficiencies in Pediatrics". The role of the nutrition specialist in patient care: Pathogenesis, diagnosis, and therapy of obesity and other nutritional disorders, Co-sponsored by the North American Association for the Study of Obesity, American Society for Clinical Nutrition, American Dietetic Association. Milwaukee, WI, October 16, 1993.
"Carbohydrate Assimilation in the Premature Infant" (Research Seminar) and "Clinical Nutrition Deficiencies" (Pediatric Grand Rounds), University of Iowa, April 23, 1993.
"Application of Technology to Nutritional Assessment in Routine Patient Care" Workshop on Nutrition in Cystic Fibrosis (Sponsored by NIDDK and the Cystic Fibrosis Foundation), Chevy Chase, Maryland, January 11-13, 1993.
"Stable Isotopes", and "Clinical Nutritional Deficiencies", Seminar Speaker, PEW Center for Nutritional Sciences (Departments of nutrition and Pediatrics), University of Florida, Gainesville, Florida, October, 26, 1992.
"Carbohydrate Assimilation in the Premature Infant", 35th AnnualNutrition & Food Service Management Seminar, Texas Department of Mental Health and Mental Retardation and The University of Texas at Austin, April 2, 1992.
"Carbohydsrates", "Nutritional Needs of the Preterm Infant: Scientific Basis and Practical Guidelines", Mead Johnson Nutritionals, Captive Island, Florida, December 9-12, 1991.
"Dual Stable Tracer Model for Estimating Lactose (LACT) Digestibility (DIG) IN VIVO in Premature Infants", Midwest Pediatric Gut Club, Nashville, Indiana, August 2-4, 1991.
"Carbohydrate Assimilation in the Premature Infant", Perinatal Seminar, Montreal Children's Hospital, Montreal, Canada, March 8, 1991.
"Pediatric Update on Nutrition", Alcapulco, Mexico, January 27-February 1, 1991.
"Carbohydrate Assimilation in the Premature Infant", Shriners Burn Institute, Galveston, TX, February 21, 1990.

Awards:

Future Leaders Award, The Nutrition Foundation, Inc., 1980
Special Fellow, Leukemia Society of America, Inc., 1981.
Nutrition Study Section, 1989-1993
Editorial Board, Journal of Parenteral and Enteral Nutrition, 1991-
Editorial Board, American Journal of Physiology, 1992-
Ad Hoc Expert Panel: Review of infant formula nutrient requirements for preterm infants Life Sciences Research Office (FASEB), (Advisory to FDA), 1996-