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Breast Cancer

Rare-But Aggressive-Form of Breast Cancer Undetectable By Mammogram

Breast cancer experts say that paying attention to minor changes in breast appearance could save your life if you get a rare form of breast cancer.

Most women believe that having their annual mammograms and clinical breast exams is enough to catch cancer if it develops.

But breast cancer experts counsel that paying attention to even minor changes in breast appearance could save your life if you get a rare form of the disease known as "inflammatory" breast cancer. Unlike most other forms of breast cancer, they say, this disease is undetectable on a mammogram and doesn't start as a lump.

Inflammatory breast cancer starts as a tissue thickening or redness, versus a lump that can be felt so it often goes undetected until the disease has spread to the lymph nodes and possibly to other areas of the body.

There are two primary types of breast cancer:

Inflammatory breast cancer is a very aggressive form of invasive cancer caused by a build-up of breast cancer cells that block the lymphatic vessels.

The body's lymphatic system produces and stores cells to fight off infection and disease. Breast lymphatics, tiny channels similar to blood vessels, transport fluid from the breast tissue to the lymph node glands in the underarm, which in turn help to fight infection and disease. Inflammatory breast cancer cells enter directly into the lymphatic channels within the skin of the breast, causing the skin changes that are classically seen with inflammatory cancer.

Although scientists estimate that the disease represents only 1 to 5 percent of all breast cancers, it is one of the most difficult types to treat because it is often diagnosed in an advanced stage.

There is a lack of awareness about this disease, so women often dismiss the warning signs of inflammatory breast cancer because it's not obvious that something is wrong.

Those warning signs include:

Every woman should be familiar with the way her breasts look and feel normally; that way, she can quickly identify suspicious changes and have them examined immediately by a physician.

Treatment for inflammatory breast cancer typically involves chemotherapy first, to halt the spread of cancer, followed by surgery to remove the lymph nodes and breast tissue and chest radiation to kill any remaining cancer cells.

What's important is that women recognize the warning signs before the disease becomes untreatable.

This article originally appeared in UC Health Line (8/15/06), a service of the University of Cincinnati Academic Health Center Public Relations Communications Department and was adapted for use on NetWellness with permission, 2006.

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Last Reviewed: Sep 21, 2006

University of Cincinnati Jennifer B Manders, MD
Assistant Professor
Division of Surgical Oncology
Department of Surgery
College of Medicine
University of Cincinnati
Jennifer B Manders, MD

 
University of Cincinnati Zeina Nahleh, MD
Director, Breast Oncology Program
Division of Hematology/Oncology
Department of Internal Medicine
College of Medicine
University of Cincinnati
Zeina  Nahleh, MD