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Parkinson's Disease

Entacapone

08/31/1999

Question:

I wondered when/if entacapone would be approved for sale in this country. My pwp cannot take any of the agonists because of paranoia/hallucinations caused by any increase in sinemet. He is only on 3 25/100 sinemet a day and the only reason he can handle this small amount is due to the fact that he is on seroquel.

Answer:

Entacapone is undergoing the FDA approval process and should be available in the USA in the near future. One thing to remember though: entacapone acts by increasing the availability of Sinemet. Thus adding it on to Sinemet helps reduce on-off fluctuations but can also worsen dyskinesias and hallucinations. Increasing the dose of Seroquel may help control hallucinations better. Surgery, particularly pallidotomy, may be helpful in controlling dyskinesias.

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Response by:

Arif Dalvi, MD
Assistant Professor
College of Medicine
University of Cincinnati