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NetWellness provides the highest quality health information and education services created and evaluated by faculty of our partner universities.
Wednesday, November 19, 2008
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NetWellness provides the highest quality health information and education services created and evaluated by faculty of our partner universities.
Wednesday, November 19, 2008
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Parkinson's Disease |
Acetylcholinesterase inhibitors and PD11/01/1999 05:54PM |
Are you aware of any acetylcholinesterase inhibitor studies for Parkinson`s Dementia? Everything I see is for Alzheimers only.
No. In fact there is a theoretical objection to using acetylcholineesterase inhibitors in Parkinson`s disease. Part of the problem is believed to be an imbalance between the dopamine and acetylcholine systems, with reduced dopamine activity and a relatively excessive acetylcholine activity. Using acetylcholineesterase inhibitors may exacerbate this imbalance. My own experience with drugs such as Aricept has been that they do not help the dementia in the setting of PD to any significant extent and on occasion may worsen the motor symptoms.
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Arif Dalvi, MD Assistant Professor Department of Neurology College of Medicine University of Cincinnati |
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