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Inherited Disorders and Birth Defects

CAN A CLEFT PALATE BE DETECTED BEFORE PREGNAN

02/23/2000

Question:

I HAVE A BILATERAL CLEFT LIP AND PALATE I WAS WONDERINGG IF THEY CAN DETECT THIS EARLY INTO A PREGNANCY AND IF IT COULD BE REVERSED BEFORE BIRTH. ALSO, WHAT ARE THE CHANCES OF MY CHILDREN HAVING THE SAME DEFECT

Answer:

Cleft lip, with or without cleft palate, is a very common birth defect. About 1 out of 700 to 1000 newborns are born with a cleft lip and/or cleft palate.

Failure of the lip and/or palate (roof of the mouth) to close happens early in gestation - about 6-8 weeks of pregnancy. Cleft lip and palate can be diagnosed during pregnancy with a very good ultrasound examination, specifically looking for the abnormality - This can be diagnosed usually at about 13 weeks of gestation. Cleft palate is more difficult to diagnose during pregnancy, but can be looked for at about 18 weeks of gestation.

I am not aware of any center offering surgery during pregnancy that can correct the defect prior to the birth of the baby. Surgery following birth usually has excellent results.

Usually, isolated (no other birth defects present) cleft lip and/or cleft palate is due to a combination of genetics and environmental factors. The chance it could happen again is based on many factors including the number of affected persons in your family, the closeness (blood relation) of affected relatives, your race, your sex and the severity of the clefts. The best person to provide this information would be a geneticist or genetic counselor - they could look at your family history, and other factors, to tell you what chance your children may have of also being born with a cleft lip and palate.

You can ask your doctor for a referral or contact the National Society of Genetic Counselors below to find a genetics center near you.

There is also good information available for families with cleft lip and/or cleft palate at the Cleft Palate Foundation website below.

Related Resources:

The National Society of Genetic Counselors Resource Link
The Cleft Palate Foundation

For more information:

Go to the Inherited Disorders and Birth Defects health topic, where you can:

Response by:

Case Western Reserve University Anne Matthews, RN, PhD
Associate Professor of Genetics
Department of Genetics
School of Medicine
Case Western Reserve University
Anne   Matthews, RN, PhD