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Lupus

FANA titer

10/30/2000

Question:

A few years ago I had an FANA titer of 1:320, speckled pattern. Now, it is 1:1280, speckled. What are the implications/what does this mean? (NOTE: I have been diagnosed with Sjogren`s syndrome and my former rheumatology doctor was also monitoring me for lupus.)

Answer:

An increase in FANA titer does not necessarily mean an increase in disease activity. However, if it continues to be high, you may ask your rheumatologist for a detailed physical exam and evaluation for any flares - sometimes they require further testing for antibodies such as anti-SSA, anti-RNP and anti-DNA, complement levels, urine tests etc.

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Response by:

Ram Raj   Singh, MD Ram Raj Singh, MD
Associate Professor of Clinical Medicine
College of Medicine
University of Cincinnati