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Parkinson's Disease

Changing agonists.



If changing agonists e.g Permax to Mirapex how should the phasing out/introduction be handled. Present dose of Permax is 3mg. daily.


In my own practice I follow a method of direct dose for dose substitution. 1 mg of Mirapex replaces 1 mg of Permax. In a study, complete switching of the dose was compared with a cross taper and the former was found to result in a quicker adjustment of the dose.

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Response by:

Arif Dalvi, MD
Assistant Professor
College of Medicine
University of Cincinnati