NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Thursday, January 29, 2015
If changing agonists e.g Permax to Mirapex how should the phasing out/introduction be handled. Present dose of Permax is 3mg. daily.
In my own practice I follow a method of direct dose for dose substitution. 1 mg of Mirapex replaces 1 mg of Permax. In a study, complete switching of the dose was compared with a cross taper and the former was found to result in a quicker adjustment of the dose.
Arif Dalvi, MD
College of Medicine
University of Cincinnati