NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Thursday, April 17, 2014
Free and Total Fraction PSA Test
I asked a series of question on Friday, June 22 titled "My Third Biopsy." One of The responses was that my next PSA should include a free and total fraction. My question is what is it and what will it tell me that the PSA doesn`t?
PSA is circulating in the blood in two forms - bound to a protein and free or unbound. For reasons that are not understood patients with malignancy tend to have a lower free fraction and a ration of Free. Total is at times helpful in determining which patients with an elevated PSA who have had a negative biopsy should have a repeat biopsy. I am sure your physician should be able to discuss this with you. I hope this information is helpful.
Martin I Resnick, MD
Formerly, Professor of Urology
School of Medicine
Case Western Reserve University