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Pharmacy and Medications

Pregnancy and medication side effects

08/07/2003

Question:

i currently am taking respiradol 2mg, trazadone 200mg and xanax 1mg daily. shoud i be concerned about possible pregnancy birth defects. I have not had a period for 6 years but still have not gone through menopause.

Answer:

With regards to use during pregnancy, the Food and Drug Administration (FDA) classifies prescription and over-the-counter medications by assigning a letter to the drug that indicates the potential risk to a developing child (fetus). Five categories have been defined; A,B,C,D,and X with A being the safest, and X a drug that should be completely avoided if possible during pregnancy. For the most part, assignment to a category indicates whether or not there have been any adverse effects noticed in animal experiments with the drug, or whether any adverse effects in humans have been recorded. Sometimes the potential risk to the fetus has to be carefully weighed with the benefit of giving the drug to the mother for treatment of a medical condition. With regard to the medications you are currently taking, Risperidone (Risperdal) and Trazodone are classified as category C. This designation signifies that either studies in animals have shown harm to the fetus, or there is no study in either animal or humans available. Alprazolam (Xanax) is classified as category D, indicating that there is evidence that a risk exists in humans for possible harm to the fetus, and the benefit of using the drug needs to be assessed carefully. If you become pregnant while taking these medications, you should let your physician know immediately so he or she can assess potential risk factors and benefit in your case.

 

Prepared by Robyn Henges, PharmD candidate University of Cincinnati

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Response by:

University of Cincinnati Jan Scaglione, BS MT, PharmD ,DABAT
Assistant Professor of Pharmacy Practice
Drug and Poison Information Center
Cincinnati Children’s Hospital Medical Center
University of Cincinnati