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NetWellness provides the highest quality health information and education services created and evaluated by faculty of our partner universities.
Friday, November 20, 2009
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NetWellness provides the highest quality health information and education services created and evaluated by faculty of our partner universities.
Friday, November 20, 2009
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Pharmacy and Medications |
Piroxicam with Tylenol/Arthritis Pain05/03/2005 |
Is it safe to stake Tylenol/Arthritis Pain Extended Relief with Piroxicam (20mg.)? I also take Lisinopril 10mg., Levoxyl 75 mcg., and Lovastatin 20 mg.Thank you.
Tylenol (Acetaminophen) Arthritis is an over-the-counter medication used to relieve mild to moderate arthritis pain. This medication comes in caplet form and is designed to last up to 8 hours. Each caplet contains 650 mg of acetaminophen. The typical dose is two caplets (1300 mg) taken by mouth every 8 hours. The caplets should be swallowed whole; do not crush, chew, or dissolve it in a liquid. Users of this product should take no more than 6 tablets in 24 hours; also, this medication should be used for no longer than 10 days, unless directed to do so by a physician. Many over-the-counter cold and flu products contain acetaminophen. These should be avoided while using this medication, as taking too much acetaminophen (greater than 4,000 mg/day) can cause severe liver damage. Acetaminophen is generally well tolerated, with few side effects. However, it is important to avoid or limit alcohol to <3 drinks/day while using this medication, as concurrent use can also cause severe liver damage. Users of acetaminophen should let their physicians and other health-care providers know that they are taking this medication.Piroxicam (Feldene®), a non-steroidal anti-inflammatory drug (NSAID), is commonly used to treat pain and inflammation associated with osteoarthritis and rheumatoid arthritis. Some side effects reported with piroxicam use include gastrointestinal ulceration and bleeding, drowsiness, edema and increased sensitivity of the skin to sunlight. It is important that patients discontinue use and report any signs or symptoms of gastrointestinal bleeding (e.g. dark, tarry stools) immediately to their physicians.
The addition of acetaminophen to a medication regimen containing an NSAID can further minimize pain caused by arthritis in some patients. This additive effect is possible because these medications work in different ways. Acetaminophen works by increasing the body's overall pain threshold, while piroxicam (and other NSAIDs) works by blocking the production of substances in the body that cause pain and inflammation.
No major drug-drug interactions between acetaminophen, lisinopril, levoxyl or lovastatin have been reported. Long-term concurrent use of acetaminophen with an NSAID has been rarely reported to increase the risk of adverse effects on the kidney in some patients. Also, piroxicam (and other NSAIDs) have been shown to reduce or reverse the effects of high-blood pressure medications (e.g. lisinopril). It is important that patients taking prescription medications visit their physicians regularly so that drug effectiveness and possible side effects can be monitored.
Submitted by Nicole Cogan and Shari Scudder, PharmD candidates, University of Cincinnati
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Jan Scaglione, BS MT, PharmD ,DABAT Assistant Professor of Pharmacy Practice Drug and Poison Information Center Cincinnati Children’s Hospital Medical Center University of Cincinnati |
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