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NetWellness provides the highest quality health information and education services created and evaluated by faculty of our partner universities.
Saturday, November 21, 2009
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NetWellness provides the highest quality health information and education services created and evaluated by faculty of our partner universities.
Saturday, November 21, 2009
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Infertility |
Use of clomid & donor sperm08/22/2005 |
I have read the some fertility docs use clomid on days 3-7, where others use it on days 5-9. Why the difference? When would IUI be performed if clomid was used on days 3-7? Also- how long do frozen donor sperm live after they`ve been thawed and washed for IUI?
Question 1
Clomiphene citrate is generally used for 5 days and can be started anywhere between cycle days 2-5 with no difference in response rates, pregnancy rates, etc.(cycle day = first day of flow). The physician usually picks a "standard" day for consistency within his/her practice. In some cases, the day can be changed to accommodate work/vacation schedules, etc. For example, you will ovulate a few days later if you started the clomid on cycle day 5 instead of cycle day 2.
Question 2
For patients taking clomiphene citrate, IUI is usually timed using either ultrasound or urine LH timing. With ultrasound timing, you would have a vaginal ultrasound performed at baseline (while you are on your period and before you start the clomid), to make sure there are no residual cysts from a previous cycle. A midcycle ultrasound is then performed (usually 7-8 days after taking your last clomid tablet), looking for a mature follicle (cyst with an egg inside), usually measuring around 1.8 to 2.2 centimeters. You would then take an injection of HCG (self administered under the skin) to trigger ovulation. The IUI would be performed approximately 36 hours after the injection. With LH kit timing, you would start testing your urine for a color change with an ovulation predictor kit, around 3 days after taking your last clomid tablet. You would call the office the afternoon (before 2 pm) of a positive color change, with IUI performed the following morning. The ultrasound timing is more expensive because of the ultrasounds and office visits, but is more convenient for scheduling.
Question 3
Ejaculated sperm typically live 2-5 days within the female reproductive tract. Following sperm washing, the lifespan decreases and is thought to be 18-24 hours.
For additional questions, please feel free to access our website at www.ucfertility.com
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Daniel B Williams, MD Professor Director, Center for Reproductive Health Department of Obstetrics & Gynecology College of Medicine University of Cincinnati |
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