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High Blood Pressure

Renal artery stenosis

02/27/2006

Question:

high blood pressure meds you should not take with renal artery stenosis?

Answer:

Two classes of drugs can cause worsening of kidney function when renal artery stenosis is present:  Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs).  However,these two classes have also been shown to help preserve kidney function in may forms of kidney disease, especially diabetes.

Renal artery stenosis can cause hypertension.  In that case, ACEIs and ARBs are excellent treatment.  However, if the renal artery stenosis is severe,these two classes for drugs can cause worsening of kidney function.  In that case, these drugs must be stopped.  Angioplasty or stent placement can open up the renal artery and solve the problem.  However, risk and benefits of intervention have to be carefully considered.

In summary, ACEis and ARBs can be very helpful in renal artery stenosis, but can also be harmful, depending on the severity of the stenosis and other factors.  Each patient should be evaluated and renal artery studies should be performed if necessary, before treatment decisions can be made.

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Response by:

University of Cincinnati Max C. Reif, MD
Director, Hypertension Section
Division of Nephrology & Hypertension
Department of Internal Medicine
College of Medicine
University of Cincinnati
Max C. Reif, MD