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Myasthenia Gravis

Legatrin

10/26/2006

Question:

There is an over-the-counter drug called Legatrin which is used for relief of leg cramps, joint pain, lower backache and sore feet--and to help one get a good night`s sleep.

Legatrin contains 500mg of acetaminophen and 50 mg of "diphenhydramine hydrochloride".

Would Legatrin be safe for MG patients?

Answer:

Diphenhydramine is the generic name for “Benadryl”. This medication causes drowsiness and sedation, urinary hesitancy and memory problems as more common side - effects. It looks like the major action in this combination is as a sedative.

If your MG is completely controlled, this medication is probably safe (though I almost never use it for my patients because if the side-effects). You should also check with your neurologist who is caring for your MG. He/She may have other reasons for you not to use the medication.

For more information:

Go to the Myasthenia Gravis health topic, where you can:

Response by:

John G Quinlan, MD John G Quinlan, MD
Professor of Neurology
College of Medicine
University of Cincinnati