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Arthritis and Rheumatism

Symptoms of sero negative arthritis



Question 46213 Please explain the symptoms of sero-negative arthritis. What is the age onset, and does this kind of arthritis cause disability?


Seronegative arthritis is an umbrella term that encompasses inflammatory arthritides that do not have an associated elevation in the Anti-Nuclear Antibody (ANA) or Rheumatoid Factor (RF) blood tests. Many types of arthritides can be classified as seronegative arthritis such as Rheumatoid Arthritis (RA) with normal RF, Reactive Arthritis, and Psoriatic Arthritis, to name a few. As such, I am unable provide specific information relating to age of onset, prognosis, etc. For more information on seronegative RA, please refer to the link below.

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Rheumatoid arthritis and negative RF

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Response by:

Raymond  Hong, MD, MBA, FACR Raymond Hong, MD, MBA, FACR
Formerly, Assistant Professor of Medicine
School of Medicine
Case Western Reserve University