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Digestive Disorders

What causes acid reflux?

12/21/1998

Question:

What causes acid reflux?

Answer:

Acid reflux occurs when gastric contents leave the stomach and enter the esophagus. A certain amount of this is considered normal. When esophageal acid exposure occurs to such an extent that it causes symptoms, it is termed gastroesophageal reflux disease (GERD). Esophageal acid exposure is determined by the balance between the amount of gastric contents entering the esophagus and the rate of clearance of the material that comes up. Abnormalities of the barrier to reflux between the stomach and esophagus (which includes the diaphragm, lower esophageal sphincter and hiatal hernias), delayed emptying of the stomach and impairments in clearance of refluxate (abnormal esophageal motor function and decreased saliva production) are all contributors to GERD. Rarely is GERD due to too much acid production-it's a matter of normal amounts of stomach acid getting into the wrong places.

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Response by:

University of Cincinnati Michael Patrick Jones, MD, FACP
Director, Center for Digestive Motility Disorders
Division of Digestive Diseases
Department of Internal Medicine
College of Medicine
University of Cincinnati
Michael Patrick Jones, MD, FACP