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Sarcoidosis

Causal relationship in sarcoidosis

08/13/2007

Question:

I am Caucasian, irish by ancestry. I have sarcoidosis. I understand there is a greater incidence in the african american race. What is the possible relationship?

Answer:

The cause of sarcoidosis remains unknown, but there are certain genetic factors that appear to influence the severity of disease. The observation that sarcoidosis runs in certain families (this is relatively rare) and tends to affect certain ethnic groups more than others is an argument for a genetic predisposition to the disease. There is also strong evidence linking sarcoidosis to environmental exposures. At present, most sarcoidosis experts would agree that both genetics and environmental exposures contribute to the development of sarcoidosis.

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Response by:

Elliott D Crouser, MD Elliott D Crouser, MD
Associate Professor of Pulmonary, Allergy, Critical Care & Sleep Medicine
College of Medicine
The Ohio State University