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Arthritis and Rheumatism




I have tried many medications for my rheumatiod arthritis but still have pain, swelling and stiffness. I am currently on Enbrel, Methortexate, Arthrotec, and Prednisone. I have also Plauqenil and many different types of NSAID including Celebrex. What to do next when bioligics don`t work?


Biologics that are FDA approved for the treatment of Rheumatoid Arthritis (RA) include an antagonist to IL-1, TNF-alpha antagonists, T-cell co-stimulation blockade, and anti-B-cell therapy. Etanercept (Enbrel) is a biologic that works against TNF-alpha. If your Rheumatologist believes that you are an inadequate responder to one biologic therapy, then there are multiple other biologic medications with the same or different mechanisms of action that are possible options.

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Response by:

Raymond  Hong, MD, MBA, FACR Raymond Hong, MD, MBA, FACR
Formerly, Assistant Professor of Medicine
School of Medicine
Case Western Reserve University