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Allergies

Delayed allergic reaction to contrast medium?

12/04/2007

Question:

I had a CT scan with contrast a week ago. This past Saturday, four days after the CT scan, I started itching a lot. Sunday morning, I woke up with a rash on my back and chest. As of right now, about 85% of my body is covered in this itchy, red, tender, touch-sensitive rash. I went to an immediate care facility on Sunday, and the doctor said it looked like a type of rosacea. Yesterday, I managed to get an appointment with a dermatologist who said it looked like an allergic reaction. When we discussed the potential culprits, the only change in the past week was that CT scan with contrast. My question is, is it possible for it to take four days to express? And is it possible that the allergic reaction was there but lesser (my scalp was itchy for a few days after the test), and a stressful event could have triggered it to go "full blown"? (I bought a new car on Friday.)

Thank you!

Answer:

Delayed reactions to radiocontrast media have been report in a small percentage of patients.  I would see an allergist/immunologist in your area who is experienced in drug reactions for further evaluation and treatment. In the future, I would either avoid contrast material or be pre-treated with the standard protocol (prednisone 50mg 13, 7, 1 hour before contrast; benadryl 50 mg 1 hour before contrast and use a low osmololity contrast agent).  An alternative if contrast is absolutely required would be to use a different contrast material (i.e. gadolinium).

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Response by:

University of Cincinnati Jonathan Bernstein, MD
Associate Professor of Medicine
Division of Immunology and Allergy
Department of Internal Medicine
College of Medicine
University of Cincinnati
Jonathan   Bernstein, MD