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Friday, October 9, 2015
Bleeding and Clotting Disorders
Protein S antigen
what does a protien s antigen elevation combined with a protien activy decrease mean?
Your description of PS does not fit the usual definition so I am afraid I cannot answer your question.
Only free PS is active. Three subtypes of PS deficiency are recognized:
- type I, with decreased levels of both total and free PS antigen (i.e. a quantitative defect);
- type II, with levels of total and free PS antigen within their normal ranges, but a decreased PS activity (i.e. a qualitative defect); and
- type III, with decreased free PS antigen levels while total PS antigen levels are normal
(De Stefano et al, 1996).
Eric H Kraut, MD
Professor of Hematology
College of Medicine
The Ohio State University