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Bleeding and Clotting Disorders

Reactive thrombocytosis



my 22 year old daughter has been examined at the Mayo clinic and the hospital due to extremely high platelet count, up to 1.4 million, though no one can find the underlying cause exactly, they believe it is somehow connected to her ulcerative colitis (which is mild and not flaring up for quite some time as far as she knows)there is an extracolonic component to the inflammation is obvious from her lab work. they performed plasmapheresis but the count quickly went back to 1 million after 10 days. she is on 60 mg prednisone and they are hopeing to bring the counts down. is there any other drug less nasty that might work for her. do we need to worry about the 1 million count? she had respiratory distress off and on for about 10 months, but the prednisone has suppressed those symptoms for now. no bleeding or bruising no cancer.


Mayo clinic is one of the world experts in this problem. Distinguishing between reactive thrombocytosis and a bone marrow disease is important since there is risk of blood clots in the latter and not usually in the former. Your doctors can answer the question about therapy best.

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Response by:

Eric H Kraut, MD Eric H Kraut, MD
Professor of Hematology
College of Medicine
The Ohio State University