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Pharmacy and Medications

Can Tylenol PM be Taken 12 hours After Xanax?



I sometimes take Tylenol PM at night, but earlier today I took a .5mg Xanax. It`s been around 12 hours since I took it. My question is can I take Tylenol PM now?


Yes. Tylenol PM is a brand of acetaminophen and diphenhydramine. Xanax is a brand of the drug alprazolam. The 3 drugs are compatible, which means the drugs can be taken together.

The pharmacist who dispenses your prescriptions such as Xanax is a good source of information on using over-the-counter drugs with prescription drugs.

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Response by:

Carmen M Hadley, RPh, CSPI
Former Clinical Instructor
College of Pharmacy
The Ohio State University