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Kidney Diseases

Bartter's Syndrome

08/26/2008

Question:

Are kidney transplants ever done to cure Bartter’s Syndrome, if nothing else can be done (extreme cases)?

Answer:

Since the late 1990's, there have been sporadic case reports of successful kidney transplantation in patients with Bartter's syndrome.  The group at Stanford most recently reported transplantation to treat a patient with severe electrolyte abnormalities, even before the development of end-stage renal disease (Pediatr Transplant 2006; 10:266-270).

Use of this strategy must carefully weigh the benefits of eliminating the native kidneys as the source of the electrolyte abnormalities against the risks of life-long immunosuppression needed to sustain the transplanted kidney (renal allograft).

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Response by:

Donald E Hricik, MD Donald E Hricik, MD
Professor of Medicine
Chief of the Division of Nephrology and Hypertension
School of Medicine
Case Western Reserve University