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Is sinus medication safe during pregnancy?



I have read several conflicting sources regarding the safety of sinus medications such as Benadryl Allergy & Sinus and Sudafed PE Sinus Headache during pregnancy. Are either of these medications safe to take? The active ingredients are Phenylephrine HCI (5 mg) and Diphenhydramine HCI (12.5 mg). Thanks!


These are considered safe in pregnancy but, as with all medications, it is best to avoid unless needed.

For more information:

Go to the Pregnancy health topic, where you can:

Response by:

Arthur T Ollendorff, MD Arthur T Ollendorff, MD
Associate Professor of Obstetrics and Gynecology
College of Medicine
University of Cincinnati