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Pharmacy and Medications

Can Clobetasol Cause White Patches on the Areas Applied?

11/21/2008 04:17PM

Question:

I am a 27 year old woman. Couple of months ago I had a rash on both my hands which my dermetologist asked me to treat with Clobetasol. I applied it regularly for 2 months twice a day. After 2 months I noticed that where ever I applied clobetasol it was all red in those areas and I had a burning sensation in that area; it was a bit painful too. My doctor said it could be because I applied too much Clobetasol and asked me to stop using it completely. I haven`t applied anything on my hands since then and the red mark and burning sensation is also completely gone. It`s been a month since I stopped using this clobetasol. But since then I have noticed a white color on my skin whereever I applied the clobetasol. I also noticed that there is no hair growing in that area. I can see hair growing around the white area but not inside the white area. Could it be a side effect of long time use of Clobetasol? Can long term using of Clobetasol cause white mark on the skin? When can I expect to get my normal skin color on those area back? Thanks!

Answer:

Adverse effects reported in clinical trials after skin application of clobetasol, included burning, stinging, irritation, and itching at the sites of application. Less commonly, skin atrophy and reduced pigmentation (lighter than normal) have been reported.

As you describe, most of these adverse effects resolve shortly after stopping the treatment. However, complete clearing of the skin discoloration may take up to a year, though most patients clear within a month or two.

This response was prepared in part by Noor Amara, PharmD student at the University of Cincinnati College of Pharmacy.

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Response by:

Cincinnati Children’s Hospital Medical Center Robert James Goetz, PharmD, DABAT
Assistant Professor of Pharmacy Practice
Drug and Poison Information Center
Cincinnati Children’s Hospital Medical Center
University of Cincinnati