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NetWellness provides the highest quality health information and education services created and evaluated by faculty of our partner universities.
Thursday, February 9, 2012
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NetWellness provides the highest quality health information and education services created and evaluated by faculty of our partner universities.
Thursday, February 9, 2012
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Pharmacy and Medications |
What is the Difference Between Indapamide and Ditide?11/12/2008 |
I am takinh Indapapmide 1.5 SR. However, I consulted internist who suggested to take cheaper Ditide (Benzthiazide-25 + Triamterene-50 mg). My question is What is the difference between Benzthiazide and Hydrochlorothiazide? He suggetsed to take Ditide 1/2 tablet instaed of full. Why is that? Can Ditide be a substitute of Indapamide. Ditide is costing around Rs 30/- whereas Indapamide is Rs 75/-. Earlier I have taken HCTZ 25 and later switched on to Indapamide. Can you advise please?
First, benzthiazide and hydrochlorothiazide (HCTZ) are similar medications. They are both members of a class of medications called “thiazide diuretics”. They both work in your kidney to increase water removal from your body and thus exert their anti-hypertensive effects. As for why your internist suggested to take ½ tablet instead of a full, I can only assume that when you were taking HCTZ 25mg that you had sufficient control of your blood pressure. Benzthiazide 25mg and HCTZ 25mg should have a similar antihypertensive effect. That said, the combination of benzthiazide and triamterene could lower your blood pressure in a similar fashion to HCTZ 25mg but with a lower dose. Substituting dytide for indapamide would be acceptable, but the dosing might be different. Where benzthiazide is a thiazide diuretic, indapamide is a “thiazide-like” diuretic. This means indapamide exerts its effect in the kidney similarly to benzthiazide, but indapamide also produces another effect directly on blood vessels that reduces total peripheral resistance. This means indapamide could potentially be a bit more effective as an antihypertensive than benzthiazide at equivalent doses, but increasing the dose of benzthiazide could potentially be more effective than a lower dose of indapamide. As an answer to your situation, if you would like to switch antihypertensives from indapamide to dytide, I would say that this should not be a problem. Ask your physician about the switch and be sure he or she knows about the product you are currently on. Keep in mind that the SR product you are on may only require one dose daily, where a new cheaper product may require more daily doses, so the cost may go up accordingly. The switch will also require that you monitor your blood pressure more frequently for the first few weeks to ensure you are having a similar result with the new medication. Submitted by Arnold Coleman,
PharmD Candidate, The Ohio State University College of Pharmacy
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Carmen M Hadley, RPh, CSPI Clinical Instructor Central Ohio Poison Center Nationwide Children’s Hospital College of Pharmacy The Ohio State University |
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