Home HealthTopics Health Centers Reference Library Research
Join us on Facebook Join us on Facebook Share on Facebook

Pharmacy and Medications

Is Paxil More Effective Than Lexapro for Helping with Premature Ejaculation?

12/23/2008

Question:

Which is most effective for premature ejaculation: Paxil or Lexapro? In fact I am taking Lexapro 10 for anxiety but as of late I have a problem of premature ejaculation. Doctor advised to stop Lexapro 10 and start Paxil 20 before coitus. Can you guide me as to the better effictive drug for premature ejaculation Paxil 20 or Lexapro 10?

Answer:

Thank you for visiting NetWellness. There are not any head-to-head data (studies that compare one agent to another agent) comparing Escitalopram and Paroxetine for the treatment of PE. In placebo (inactive drug vs active drug) controlled trial conduct by Safarinejad MR. in the Journal of Clinical Psychopharmacology (J Clin Psychopharmacol. 2007 Oct;27(5):444-50.) concluded the drug to be effective, but further studies were indicated for final conclusions.

There are many published articles on the use of paroxetine and its use in PE. Objective results are usually seen after two weeks treatment with paroxetine, with prolongation to ejaculation time ranging between 6 to 10 minutes compared to less than 1 minute at baseline. Significant subjective changes included increased sexual desire, partner satisfaction, and decreased anxiety. However, over 90% will relapse to baseline functional status within two to three weeks after discontinuing medication.

On-demand treatment with SSRIs generally exert much less ejaculation delay than daily SSRI treatment. (Ludovico et al, 1996; McMahon & Touma, 1999; Waldinger MD et al, 2007).

On this site, we try to answer general questions about medications but cannot diagnose or recommend treatment. I encourage you to discuss these treatment options at further length with your prescriber.

For more information:

Go to the Pharmacy and Medications health topic, where you can:

Response by:

The Ohio State University Sarah Hudson-DiSalle, PharmD, RPh
Specialty Practice Pharmacist
Department of Pharmacy
The Ohio State University Medical Center
The Ohio State University