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Heart Failure

Understanding A 2D Echo

01/07/2009

Question:

My relative aged 53 years with dyslipidemia on attorvastatin 10 has a dystolic dysfunction on 2D Echo with EF 56%.  He is a non-diabetic,non smoker and normotensive. Family history for IHD CAD. His weight is 60 kilograms height 160 cms. Does he requires any work up or medication for finding of dystolic dysfunction on 2D echo?

Answer:

Diastolic dysfunction is an early form of heart failure.  It is caused by an increase in the size of the heart muscle, which leads to a smaller interior size of the left ventricle.  The most common cause is high blood pressure.  If untreated, diastolic dysfunction tends to get worse and lead to more severe forms of heart failure.

There are no established guidelines how to treat diastolic dysfunction, but a few principles are generally accepted:

- Blood pressure needs to be treated aggressively, if possible down to a systolic (the upper number) of 120 mmHg.

- Because most diastolic dysfunction is a result of left ventricular hypertrophy (LVH), blood pressure drugs that improve LVH should be given preference.  Such drugs are ACE inhibitors and angiotensin receptor blockers (ARBs)

- Medications should be combined to lead to a heart rate of about 60 per minute.  A rapid resting heart rate makes the heart less efficient.

- The only large prospective study in diastolic dysfunction has shown that candesartan, a blood pressure drug of the ARB class, improves outcome and reduces the risk of hospitalization.

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Response by:

University of Cincinnati Max C Reif, MD
Professor of Medicine
Director of Hypertension Section
Division of Nephrology & Hypertension
Department of Internal Medicine
College of Medicine
University of Cincinnati
Max C Reif, MD