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Arthritis and Rheumatism

Rheumatoid Arthritis Treatments



I have sevre RA and have tried all the treatments out there, resulting in very little help. Are there any new treatments coming down the pike for RA?


Yes, there are many agents that are being explored as therapeutics for Rheumatoid Arthritis (RA). Whether or not these agents will have the appropriate balance of effectiveness and safety is unknown. Two agents that relatively mature in their investigational process have different mechanisms of action. One agent inhibits the effect of an inflammatory cytokine known as IL-6. If FDA-approved, it would be the first medicine of its kind to treat RA with this mechanism of action. Another agent inhibits the effect of TNF-alpha, similar to adalimumab (Humira), etanercept (Enbrel), and infliximab (Remicade). This agent is already FDA-approved for the treatment of an inflammatory bowel disease known as Crohn's Disease.

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Response by:

Raymond  Hong, MD, MBA, FACR Raymond Hong, MD, MBA, FACR
Formerly, Assistant Professor of Medicine
School of Medicine
Case Western Reserve University