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Allergic reaction after years of use



Is it possible to all of a sudden become allergic to ibuprofen (Advil) after years of using it and not having any reaction? Could a illness or disease cause this? Just this month I noticed that I started breaking out in hives (under my eye) after taking Advil. I have been taking it for years for my menstrual cramps and I have not had any side effects. Just this month I noticed that a couple hours after I took it I started to get itchy bumps under my eye. It got to the point where I had many small bumps under my eye. I have gotten this before but when cleaning the house from all the dust,etc. Your response would be much appreciated.


Yes, it is possible to have a reaction to Ibuprofen (Advil) at any time.  I would recommend discontinuing all Non-steroidal anti-inflammatory agents until you see a board certified allergist experienced in the management of hives and drug reactions.

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Response by:

Jonathan   Bernstein, MD Jonathan Bernstein, MD
Associate Professor of Medicine
College of Medicine
University of Cincinnati