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Lung Transplantation

Can High Antibody Levels Be Reduced?



If a patient has high antibody levels, is there anything that they can do about this? Is it possible to reduce the level of antibodies?


High pre-formed antibody levels are a complicating factor during lung transplantation. These are found in women with multiple births or in a patient that may have received multiple blood transfusions. Generally, careful donor organ matching before transplantation and the consideration of a number of different treatments around the time of transplant is the way most transplant centers treat this potential problem.

High pre-formed antibodies in heart transplant recipients are occasionally treated with medicines or treatments to reduce the antibody production prior to transplant.

No simple treatments, diet or lifestyle modification would be expected to change the antibody levels.

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Response by:

Robert  Schilz, DO, PhD Robert Schilz, DO, PhD
Associate Professor of Medicine
School of Medicine
Case Western Reserve University