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Pharmacy and Medications

Tylenol PM & Clonazepam



I take 1 mg clonazepam at night for my parasomnia-active sleeping. I also have been taking Tylenol PM along with it for over a year now. Are there any long term side effects taking the Tylenol PM and/also clonazepam? Thank You.


Chronic use of Tylenol-PM tends to be less effective when taken chronically as you described. Also, if Tylenol is taken more frequently then you describe, it has the potential to have an effect on the liver. Taken in the manner that you have written, this is probably not a problem. Intermittent evaluation by your physician will minimize potential risks.

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Response by:

Nicholas A Votolato, RPh BCPP Nicholas A Votolato, RPh BCPP
Assistant Professor of Pharmacy
College of Pharmacy
Assistant Professor of Psychiatry, Emeritus
College of Medicine
The Ohio State University