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Pharmacy and Medications

I Take a Combination of Meds, is it Safe?

02/02/2010

Question:

should i take Cymbalta, Savella, xanax, Glipizide, Metformin, Phentermine, Neurontin, loratab together

Answer:

You should speak with either a physician or a pharmacist in person about this combination of medications. 

Duloxetine (Cymbalta) and milnacipran (Savella) are very similar medications which affect both serotonin and norepinephrine receptors. In addition, phentermine has a mechanism of action involving norepinephrine. The combination of all three of these agents would not be recommended. 

The alprazolam (Xanax), metformin, glipizide, gabapentin (Neurontin) and combination hydrocodone/acetaminophen (Lortab) are safe to take together assuming that you are not driving or operating heavy machinery after taking the alprazolam and hydrocodone/acetaminophen.

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Response by:

Michael Ganio, PharmD Michael Ganio, PharmD
Clinical Applications Pharmacist
Wexner Medical Center
The Ohio State University