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Pain Management




What is the difference between MOBIC and MOTRIN ?


They are both NSAIDs (non-steroidal anti-inflammatory drugs) that may work on inflammatory pain and may reduce fever. NSAIDs work by blocking cyclooxygenase (COX) enzymes. There are 2 COX enzymes (COX-1 and COX-2). Mobic may block COX-2 a little more than COX-1 whereas Motrin may block both equally. Blocking COX-2 selectively may be desirable to decrease risk of stomach ulcer or bleeding (however, some have argued that it may increase the risk of clotting in the vessels leading to heart attack---a very small risk). Both drugs consumed over a long period of time may be bad for the kidney. There have been no studies that have shown one NSAID to be a superior pain reliever to another NSAID.

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Response by:

Salim M Hayek, MD, PhD Salim M Hayek, MD, PhD
Associate Professor of Anesthesiology & Perioperative Medicine
School of Medicine
Case Western Reserve University