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Pharmacy and Medications




Can omeprazole be taken 10mg twice daily?


Omeprazole comes as a delayed-release capsule (Prilosec), a nonprescription delayed-release tablet (Prilosec OTC), a powder for suspension (ZegeridĀ®), and a regular capsule (Zegerid). The powder and regular capsule also contain sodium bicarbonate, a medication that decreases the amount of acid in the stomach and helps omeprazole to work quickly. The delayed-release capsules are usually taken once a day before a meal, but may be taken twice a day when used with other medications to eliminate H. pylori or up to three times a day when used to treat conditions in which the stomach produces too much acid. The capsules are usually taken once a day in the morning on an empty stomach 1 hour before a meal. The powder is usually taken once a day on an empty stomach one hour before a meal either in the morning or at bedtime. The nonprescription delayed-release tablets are usually taken once a day in the morning before eating. The nonprescription tablets should be taken for 14 days in a row, and additional 14-day treatments may be repeated once every 4 months if needed.

To help you remember to take omeprazole, take it at around the same time(s) every day. Follow the directions on your prescription label or the package label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take omeprazole exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor or stated on the package.

Omeprazole is often taken once daily. For certain medical conditions, twice daily therapy may be appropriate. The web link below is the source of the above information on omeprazole dosage forms. 

Your doctor should help you determine which dosage schedule is right for you based on the problem being treated. 

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Response by:

Carmen M Hadley, RPh, CSPI
Former Clinical Instructor
College of Pharmacy
The Ohio State University