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Pharmacy and Medications

Progesterone Dose During Pregnancy



Is 200mg of progesterone vaginally 3 times daily an excessive dose for maintenance of pregnancy? Would it matter if the person had factor v leiden?


This is a difficult one. The American College of Obstetrics and Gynecology endorses a protocol of progesterone 100 mg vaginal suppositories once daily or progesterone 250 mg IM once weekly in women with a history of preterm delivery. Your condition may require a higher dosage.  You should ask your doctor if he/she has a primary reference for the dose he/she is using. Perhaps this high dose is just for a short period of time, like a loading dose, and the plan is to lower it to once daily at a later date.

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Response by:

Debra K Gardner, PhamD Debra K Gardner, PhamD
Assistant Clinical Professor of Pharmacy
College of Pharmacy
The Ohio State University