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Pharmacy and Medications

Mixing of Medication

02/24/2011

Question:

I would like to know if I should be mixing these medications together and what foods should not be eaten with them.Gemfibrozil 600mg,Premarin 1.25mg,Plavix 75mg,Metoprolol succ er 50mg,Hydrochlorothiazide 50mg,Aspirine 81mg,B-12 500mcg,A 5,000Iu,D 400Iu,Beta Carotene 25,000Iu,Folic Acid 800mcg,Vit-E 400 Iu ,Potassium Gluconate 550mg.

Answer:

Thank you for contacting NetWellness. There is one major interaction with two of your medications that you need to speak with your physician about. The combination of Plavix® (Clopidogrel) and gemfibrozil will result in the Plavix® being less effective (not working as it should) and cause the medication not to be broken down correctly. The result of the Plavix not breaking down correctly may lead to your platelets being less able to clot, which then may cause the stent that has placed to fail.

There are not any other significant interactions with your medications and nutritional supplements.

Grapefruit juice will interact with Premarin ® and should be avoided, and the metoprolol should not be taken with food as both will increase the medications respectively.

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Response by:

Sarah Hudson-DiSalle, PharmD, RPh
Specialty Practice Pharmacist of Outpatient Pharmacy
College of Medicine
The Ohio State University