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Pharmacy and Medications

Is Cardioselectivity of Nebivolol Absolute?

11/10/2011

Question:

is cardioselectivity of nebivolol is absolute ?

Answer:

Nebivolol is highly selective for ß1 receptors in the heart at doses 10mg or less. In poor metabolizers and at doses greater than 10mg, nebivolol loses its cardioselectivity exhibiting inhibition of both ß1 receptors in the heart and ß2 receptors in the lungs.

References: Haines, Stuart, PharmD. American Pharmacists Association. New Product Bulletin BystolicTM(nebivolol). 2008: p.7


Danielle Henninger, PharmD Candidate
University of Toledo College of Pharmacy

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Response by:

David Baker, PharmD, DABAT
Formerly, Clinical Assistant Professor of Pharmacy
College of Medicine
The Ohio State University