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Mdma-effexor interaction



how do effexor and mdma(ectasy) interact. can the effexor cancel out the effects of this illicit drug?


Ecstasy (MDMA) is an illicit drug derived from the stimulant methamphetamine, while Effexor (venlafaxine) is an antidepressant. Both agents increase the brain chemicals noradrenaline, serotonin, and dopamine in the brain, but by different mechanisms. Since Ecstasy is an illegal drug, documented drug interactions are few. However, serotonin syndrome, a severe condition usually requiring hospitalization, has been reported with the use of each agent. Symptoms include altered consciousness, irritability, tremors, elevated temperature, and increased muscle tone. Therefore, combined use of these agents may be concerning. Other antidepressants affecting the neurotransmitter serotonin have been reported to interfere with the effects of Ecstasy in animals. While no such data are reported for Effexor, a similar interaction is possible. It is also important to note the many adverse effects of Ecstasy use. Long-term effects may include depression, fatigue, anxiety, panic disorder, psychosis, and destruction of serotonin nerve terminals in the brain.

Answered by: C. Cristiani, R.Ph.

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