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Infertility

Low Estradiol and Infertility

04/08/2010

Question:

Dear Doctor I am a 37 year old single woman . About a year ago,shortly after a death in the family, a very stressful phase, I noticed a reduction in the duration of menstrual flow from 4 days to 2 days and also reduction in amount of flow. Also a gradual increase in hair growth on the thighs and vaginal dryness.My cycles continued to be regular at 27-30 days . I got my hormone levels checked last may- my thyroid profile was normal,FSH 6.7,LH 8.7,prolactin 15.7, progesterone 5.22nmol/l ,estradiol 66pmol/l,testosterone 0.6nmol/l,,s.cortisol 195 nmol/l. The normal reference range given by the lab for estradiol in follicular phase was 97-592pmol/l and for progesterone as 0.44-6.4nml/l. A pelvis ultrasound showed bilateral polycystic pattern, One ovary 3 by 2 cm, other 4 by 2cm.

Checked again last week and the results are thyroid profile normal,FSH 6.6,LH 5.9,prolactin 23, progesterone 3,0nmol/l ,estradiol 51.2 pmol/l,testosterone 0.8nmol/l,,s.cortisol 301 nmol/l.DHEAS is 144.

I am distressed by the very low estradiol level of 51.2 pmol/l, , The normal reference range given by the lab for estradiol in follicular phase was 97-592pmol/l. They seem low even for the post menopausal reference range of 19-141…does this indicate perimenopause.or that menopause will occur very soon. Is there is a possibility of conceiving naturally and a successful pregnancy with such levels. My gynac has suggested I start Metformin,but from what I could gather from the internet, Im not sure I qualify as PCOD.

I am likely to get married quite soon and would like to discuss with my partner beforehand my chances of conceiving if any.

Answer:

Thank you for visiting NetWellness. On this site, NetWellness experts try to answer general questions about health. Only a health professional performing a thorough clinical exam is able to evaluate your symptoms. However, NetWellness may have some general information available that you can access through our search feature. Feel free to write back if you still have questions or need an explanation.

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