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Pharmacy and Medications




how long does lortab stay in your system?


Thank you for contacting Net Wellness. Hydrocodone/acetaminophen (lortab®) is a narcotic pain reliever. The time for the medication to begin working usually is 10 to 20 minutes and it’s duration of pain relief is between 4 and 8 hours. The drug is broken down into non-active components that take 23 to 30 hours to eliminate the hydrocodone and 7 to 21 hours to eliminate the acetaminophen from the body by your kidneys. Thanks for your question. 

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Response by:

Sarah Hudson-DiSalle, PharmD, RPh
Specialty Practice Pharmacist of Outpatient Pharmacy
College of Medicine
The Ohio State University