Head and Neck Cancer

Risk Factors for Head and Neck Cancer

Head and Neck Cancer is largely a cancer of behavior. The most important risk factors for head and neck cancers are:

Tobacco (including smokeless tobacco, sometimes called "chewing tobacco" or "snuff")
Alcohol use (related to cancers of the oral cavity, oropharynx, hypopharynx, and larynx)

85% of head and neck cancers are linked to tobacco use.

People who use both tobacco and alcohol are at greater risk for developing these cancers than people who use either tobacco or alcohol alone.

Other risk factors for cancers of the head and neck include the following:

Sun exposure (for skin and lip cancer)
HPV infection
Radiation to the head and neck
Industrial exposures, such as wood or nickel dust inhalation
Asian, particularly Chinese, ancestry (for nasopharyngeal cancer)
Epstein-Barr virus infection
Consumption of certain preservatives or salted foods
Poor oral hygiene
Use of mouthwash that has a high alcohol content is a possible, but not proven, risk factor
Plummer-Vinson (also called Paterson-Kelly) syndrome, a rare disorder that results from iron and other nutritional deficiencies. This syndrome is characterized by severe anemia and leads to difficulty swallowing due to webs of tissue that grow across the upper part of the esophagus.
Immigrants from Southeast Asia who use paan (betel quid) in the mouth should be aware that this habit has been strongly associated with an increased risk for oral cancer.
Consumption of mate, a tea-like beverage habitually consumed by South Americans, has been associated with an increased risk of cancers of the mouth, throat, esophagus, and larynx.

People who are at risk for head and neck cancers should talk with their doctor about ways they can reduce their risk. They should also discuss how often to have checkups.

Source: National Cancer Institute - Head and Neck Cancer: Questions and Answers

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Last Reviewed: Jun 18, 2009

Pierre Lavertu, MD, FRCS(C), FACS
Professor of Otolaryngology-Head and Neck Surgery
Department of Otolaryngology Head and Neck Surgery
School of Medicine
Case Western Reserve University

Head and Neck Cancer

Risk Factors for Head and Neck Cancer

Other risk factors for cancers of the head and neck include the following:

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